Glycosylation of autoantibodies in autoimmunes diseases

Protein glycosylation is one of the most common post-translational modifications, involved in the well described protein biosynthesis process. Protein glycosylation seems to play a major role in the pathogenesis of auto-immune diseases. Herein are described the main alterations of autoantibody glyco...

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Bibliographic Details
Published in:La revue de medecine interne 2013-12, Vol.34 (12), p.746-753
Main Authors: Goulabchand, R, Batteux, F, Guilpain, P
Format: Article
Language:fre
Subjects:
Animals
Autoantibodies - metabolism
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
Autoimmune Diseases - therapy
Epitopes - metabolism
Glycosylation
Granulomatosis with Polyangiitis - immunology
Granulomatosis with Polyangiitis - metabolism
Humans
Immunoglobulins, Intravenous - therapeutic use
Immunomodulation
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Summary:Protein glycosylation is one of the most common post-translational modifications, involved in the well described protein biosynthesis process. Protein glycosylation seems to play a major role in the pathogenesis of auto-immune diseases. Herein are described the main alterations of autoantibody glycosylation associated with autoimmunes diseases such as rheumatoid arthritis, IgA glomerulonephritis, Schoenlein-Henoch purpura, Sjögren's syndrome, systemic scleroderma, systemic lupus erythematosus, myasthenia gravis and granulomatosis with polyangiitis (Wegener). Molecular identification of altered immunoglobulin glycosylation could lead to a better understanding of the pathogenesis of those diseases, might allow an evaluation of their biological activity and could even be a new therapeutic target.
ISSN:1768-3122
DOI:10.1016/j.revmed.2013.09.005