Bleeding‐related symptoms in colorectal cancer: a 4‐year nationwide population‐based study

Summary Background Little is known about the major presenting features of patients with colorectal cancer (CRC) in a population‐based setting, especially regarding bleeding‐related symptoms. Aim To determine the proportion of CRC patients presenting with bleeding‐related symptoms, to compare bleeder...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2014-01, Vol.39 (1), p.77-84
Main Authors: Hreinsson, J. P., Jonasson, J. G., Bjornsson, E. S.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anemia, Iron-Deficiency - diagnosis
Anemia, Iron-Deficiency - epidemiology
Anticoagulants - adverse effects
Aspirin - adverse effects
Biological and medical sciences
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Hemorrhage - diagnosis
Gastrointestinal Hemorrhage - epidemiology
Gastrointestinal Hemorrhage - etiology
Hemorrhage - diagnosis
Hemorrhage - epidemiology
Hemorrhage - etiology
Humans
Iceland - epidemiology
Male
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Occult Blood
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Warfarin - adverse effects
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Summary:Summary Background Little is known about the major presenting features of patients with colorectal cancer (CRC) in a population‐based setting, especially regarding bleeding‐related symptoms. Aim To determine the proportion of CRC patients presenting with bleeding‐related symptoms, to compare bleeders and nonbleeders and to explore the role of anticoagulants in bleeders. Methods This was a nationwide, population‐based, retrospective study, investigating all patients diagnosed with CRC in Iceland from 2008 to 2011. Bleeding‐related symptoms were defined as overt bleeding, iron deficiency anaemia or a positive faecal occult blood test. Obstructive symptoms were defined as a confirmed diagnosis of ileus or dilated intestines on imaging. Results Data were available for 472/496 (95%) patients, males 51%, mean age 69 (±13) years. In all, 348 (74%) patients had bleeding‐related symptoms; of these 348 patients, 61% had overt bleeding. Bleeders were less likely than nonbleeders to have metastases at diagnosis, 19% vs. 34% (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.12519