Development of Serum Iron as a Biological Dosimeter in Mice

Even though serum iron is a commonly used parameter in iron metabolism, it has not yet been applied for biological dosimetry purpose. A new biological dosimeter based on serum iron has been developed in this work. Serum iron levels in mice subjected to gamma rays from a 60Co source were detected wit...

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Bibliographic Details
Published in:Radiation research 2013-06, Vol.179 (6), p.684-689
Main Authors: Zhang, Xiao-hong, Lou, Zhi-chao, Wang, Ai-lian, Hu, Xiao-dan, Zhang, Hai-qian
Format: Article
Language:English
Subjects:
Animals
Biological
Biological markers
Biomarkers
Blood
Dosage
Dose response relationship
Dosimeters
Dosimetry
Gamma Rays - adverse effects
Ionizing radiation
Ions
Iron
Iron - blood
Irradiation
Male
Mice
Mice, Inbred ICR
Radiation dosage
Radiation dose response relationship
Radiometry
Radiometry - methods
REGULAR ARTICLES
Serums
Space life sciences
Time Factors
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Summary:Even though serum iron is a commonly used parameter in iron metabolism, it has not yet been applied for biological dosimetry purpose. A new biological dosimeter based on serum iron has been developed in this work. Serum iron levels in mice subjected to gamma rays from a 60Co source were detected with the use of ferrous. The doses are from 0.2–7 Gy with a dose rate of 0.2 Gy/min. The results demonstrate that serum iron level increases with increasing dose. The detection limit based on serum iron has a lower limit of dose detection of about 0.5 Gy and the maximal increase of serum iron observed is maintained 4 h after γ irradiation. Therefore the best suggested time for blood collection is within 4 h after γ irradiation. Two dose-response relationships were observed with both according to degrees of the increase of serum iron levels and different intervals after γ irradiation. The first is a linear relationship of y = 0.98x + 6.76 (r = 0.98) obtained 10 min after γ irradiation; the second is the linear quadratic relationship of y = −0.07x2 + 1.02x + 6.45 (r = 0.99) obtained 7 days after γ irradiation. The absorbed doses of mice estimated with the use of both these two dose-response relationships were close to the actual dose of 1 Gy. It is concluded that serum iron is a quick, simple and sensitive biomarker for early assessment of the absorbed dose of mice.
ISSN:0033-7587
1938-5404
DOI:10.1667/RR3142.1