Effect of nonsurgical periodontal therapy on serum and gingival crevicular fluid cytokine levels during pregnancy and postpartum

Background and Objective:  A low‐grade systemic inflammatory status originating from periodontal infection has been proposed to explain the association between periodontal disease and systemic conditions, including adverse obstetric outcomes. The aim of this study was to evaluate the effect of perio...

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Bibliographic Details
Published in:Journal of periodontal research 2013-02, Vol.48 (1), p.126-133
Main Authors: Fiorini, T., Susin, C., da Rocha, J. M., Weidlich, P., Vianna, P., Moreira, C. H. C., Bogo Chies, J. A., Rösing, C. K., Oppermann, R. V.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Biological and medical sciences
Biomarkers - analysis
Biomarkers - blood
cytokines
Cytokines - analysis
Cytokines - blood
Dental Calculus - therapy
Dental Plaque - therapy
Dental Scaling - methods
Dentistry
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gingival Crevicular Fluid - chemistry
Humans
inflammation
inflammatory mediator
Interleukin-10 - analysis
Interleukin-10 - blood
Interleukin-12 - analysis
Interleukin-12 - blood
Interleukin-1beta - analysis
Interleukin-1beta - blood
Interleukin-6 - analysis
Interleukin-6 - blood
Interleukin-8 - analysis
Interleukin-8 - blood
Medical sciences
Non tumoral diseases
nonsurgical periodontal therapy
Oral Hygiene
Otorhinolaryngology. Stomatology
Periodontal Attachment Loss - therapy
Periodontal Diseases - complications
Periodontal Diseases - therapy
Periodontal Index
periodontal medicine
Periodontal Pocket - therapy
Postpartum Period - blood
Postpartum Period - metabolism
Pregnancy
Pregnancy Complications, Infectious - therapy
Pregnancy Outcome
Pregnancy Trimester, Second - blood
Pregnancy Trimester, Second - metabolism
Premature Birth - blood
Premature Birth - metabolism
Root Planing - methods
systemic host effect
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:Background and Objective:  A low‐grade systemic inflammatory status originating from periodontal infection has been proposed to explain the association between periodontal disease and systemic conditions, including adverse obstetric outcomes. The aim of this study was to evaluate the effect of periodontal therapy during pregnancy on the gingival crevicular fluid and serum levels of six cytokines associated with periodontal disease and preterm birth. Material and Methods:  A subsample of 60 women (18–35 years of age) up to 20 gestational weeks, previously enrolled in a larger randomized clinical trial, was recruited for the present study. Participants were randomly allocated to receive either comprehensive nonsurgical periodontal therapy before 24 gestational weeks (n = 30, test group) or only one appointment for supragingival calculus removal (n = 30, control group). Clinical data, and samples of blood and gingival crevicular fluid, were collected at baseline, at 26–28 gestational weeks and 30 d after delivery. The levels of interleukin (IL)‐1β, IL‐6, IL‐8, IL‐10, IL‐12p70 and tumor necrosis factor‐α were analyzed by flow cytometry. Results:  After treatment, a major reduction in periodontal inflammation was observed in the test group, with bleeding on probing decreasing from 49.62% of sites to 11.66% of sites (p 
ISSN:0022-3484
1600-0765
DOI:10.1111/j.1600-0765.2012.01513.x