Effects of the genetic pattern defined by low-density lipoprotein receptor and IL28B genotypes on the outcome of hepatitis C virus infection

The aim of this study was to assess the impact of the genetic pattern (GP) defined by the single nucleotide polymorphisms (SNPs) rs14158 of low-density lipoprotein receptor (LDLR) and rs12979860 of interleukin-28B (IL28B) genes on the outcome and features of hepatitis C virus (HCV) infection in pati...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2013-11, Vol.32 (11), p.1427-1435
Main Authors: Di Lello, F. A., Caruz, A., Rallon, N. I., Rivero-Juarez, A., Neukam, K., Barreiro, P., Camacho, Á., García-Rey, S., Rivero, A., Soriano, V., Cifuentes, C., Macias, J., Pineda, J. A.
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Female
Genotype & phenotype
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
HIV
HIV Infections - complications
Human immunodeficiency virus
Human viral diseases
Humans
Immune system
Infections
Infectious diseases
Interferons - therapeutic use
Interleukins - genetics
Internal Medicine
Lipoproteins
Low density lipoprotein receptors
Male
Medical Microbiology
Medical sciences
Middle Aged
Plasma
Polymorphism, Single Nucleotide
Receptors, LDL - genetics
Ribavirin - therapeutic use
Treatment Outcome
Viral diseases
Viral hepatitis
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Summary:The aim of this study was to assess the impact of the genetic pattern (GP) defined by the single nucleotide polymorphisms (SNPs) rs14158 of low-density lipoprotein receptor (LDLR) and rs12979860 of interleukin-28B (IL28B) genes on the outcome and features of hepatitis C virus (HCV) infection in patients with and without human immunodeficiency virus (HIV) coinfection. 314 HIV/HCV-coinfected and 109 HCV-monoinfected patients treated with pegylated interferon (Peg-IFN) plus ribavirin (RBV), as well as 51 patients with HCV spontaneous clearance (SC), were included. Variations in both SNPs were determined by the TaqMan polymerase chain reaction (PCR) assay. In the 286 patients chronically infected by HCV genotypes 1 or 4, both rs14158 CC and rs12979860 CC were associated with a higher rate of sustained virological response (SVR), and these effects were complementary in both HCV-monoinfected and HIV/HCV-coinfected patients. Thus, 24 % of patients with rs14158/rs12979860 TT-TC/TT-TC, 33 % with TT-TC/CC, 44.2 % with CC/TT-TC, and 75.8 % harboring CC/CC attained SVR ( p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-013-1894-9