The effects of Rhizoma drynariae on interleukin-2 and T-lymphocyte levels in rats after severe head injury

To investigate the effects of Rhizoma drynariae on the levels of interleukin-2(IL-2) and T-lymphocyte subset in rats with severe head injury (SHI). 72 Sprague Dawley (SD) rats were randomly divided into 3 groups: control group, model group, and R. drynariae group. The experimental group received int...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2012-06, Vol.142 (1), p.300-304
Main Authors: Wang, Wen-zhu, Pan, Yu-zheng, Wei, Jing-bin, Huang, Li-ping, Huang, Xi, Li, Kai
Format: Article
Language:English
Subjects:
Animals
CD3 antigen
CD3 Complex - immunology
CD4-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - drug effects
Craniocerebral Trauma - blood
Craniocerebral Trauma - immunology
Flow cytometry
Interleukin-2
Interleukin-2 - blood
Lymphocyte Count
Male
Plant Extracts - pharmacology
Plant Roots
Polypodiaceae
Rats
Rats, Sprague-Dawley
Rhizoma drynariae
Severe head injury
T-lymphocyte
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Summary:To investigate the effects of Rhizoma drynariae on the levels of interleukin-2(IL-2) and T-lymphocyte subset in rats with severe head injury (SHI). 72 Sprague Dawley (SD) rats were randomly divided into 3 groups: control group, model group, and R. drynariae group. The experimental group received intragastrical infusions of with aqueous R. drynariae extract four hours after SHI while the other groups were administered with equivalent volumes of physiological saline. Infusions were administered to the 3 groups once a day for 7d. IL-2 and T-lymphocyte (CD3, CD4, CD8) levels were measured at 24, 72, and 168h after initial infusion. The levels of IL-2 and CD4 T cells reduced obviously after 24h in the model group (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2012.04.031