Modification of polyethersulfone hemodialysis membrane by blending citric acid grafted polyurethane and its anticoagulant activity

► Citric acid was grafted onto polyurethane, used as the anticoagulant additive. ► A new activated partial thromboplastin time method was introduced in this paper. ► The blood compatibility and cytocompatibility of the blended membrane were researched. Citric acid, a widely used anticoagulant, was g...

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Bibliographic Details
Published in:	Journal of membrane science 2012-07, Vol.405-406, p.261-274
Main Authors:	Li, Lulu, Cheng, Chong, Xiang, Tao, Tang, Min, Zhao, Weifeng, Sun, Shudong, Zhao, Changsheng
Format:	Article
Language:	eng
Subjects:	adhesion adsorption anticoagulant activity anticoagulants artificial membranes biocompatibility blood coagulation Blood compatibility blood platelets blood serum bovine serum albumin calcium cattle cell adhesion citric acid Citric acid grafted polyurethane Cytocompatibility fibrinogen hemodialysis ions liver mixing Polyethersulfone membrane polymerization polyurethanes prothrombin thromboplastin
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Summary:	► Citric acid was grafted onto polyurethane, used as the anticoagulant additive. ► A new activated partial thromboplastin time method was introduced in this paper. ► The blood compatibility and cytocompatibility of the blended membrane were researched. Citric acid, a widely used anticoagulant, was grafted onto polyurethane through a two-step solution polymerization. The novel synthesized polymer can be directly blended with polyethersulfone (PES) to prepare membranes. The modified membranes showed lower protein (bovine serum albumin, BSA; bovine serum fibrinogen, BFG) adsorption and suppressed platelet adhesion. Due to the binding of calcium ions in blood, the modified membranes effectively prolonged the activated partial thromboplastin time (APTT), prothrombin time (PT), plasma recalcification time (PRT) and the whole blood clotting time (WBCT). Furthermore, the modified membranes showed good cytocompatibility, and the surfaces promoted hepatocyte adhesion and proliferation compared to pure PES membrane. These results indicated that the surface modification by blending citric acid grafted polyurethane provided practical application of the membranes with good biocompatibility, especially the anticoagulant property; and the membranes could be used in blood purification fields, such as hemodialysis and bioaritificial liver assist devices.
ISSN:	0376-7388 1873-3123