Pyruvate Ringer's Solution Corrects Lactic Acidosis and Prolongs Survival during Hemorrhagic Shock in Rats

Abstract Background Lactic acidosis is a life-threatening complication of hemorrhagic shock. There is no ideal therapy for it in the clinical setting. Objective This study was designed to investigate whether pyruvate Ringer's solution could treat hypoxic lactic acidosis associated with lethal h...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of emergency medicine 2013-12, Vol.45 (6), p.885-893
Main Authors: Hu, Sen, MD, PhD, Bai, Xiao Dong, MD, PhD, Liu, Xian Qi, MD, Wang, Hai Bin, MD, Zhong, Yu Xian, MD, Fang, Tiao, MD, Zhou, Fang Qiang, MD
Format: Article
Language:English
Subjects:
Acidosis, Lactic - drug therapy
Acidosis, Lactic - etiology
Analysis of Variance
Animals
Arterial Pressure
Carbon Dioxide - blood
Disease Models, Animal
Emergency
hemorrhagic shock
ischemic injury
Isotonic Solutions - therapeutic use
lactate
lactated Ringer's solution
Lactic Acid - blood
lactic acidosis
Male
Oxygen - blood
pyruvate
pyruvate Ringer's solution
Pyruvic Acid - blood
Pyruvic Acid - therapeutic use
Rats
Rats, Sprague-Dawley
Shock, Hemorrhagic - complications
Shock, Hemorrhagic - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Lactic acidosis is a life-threatening complication of hemorrhagic shock. There is no ideal therapy for it in the clinical setting. Objective This study was designed to investigate whether pyruvate Ringer's solution could treat hypoxic lactic acidosis associated with lethal hemorrhagic shock in rats. Methods A total of 54 rats were subjected to hemorrhagic shock with mean arterial pressure (MAP) of 40 mm Hg for 1 h. They were then randomly divided into three groups (n = 18 each): Group N had no fluid resuscitation; Group L received lactated Ringer's solution infusion; and Group P received pyruvate Ringer's solution infusion. The survival rate was investigated after 24 h. In addition, a second set of 54 rats was selected for blood sampling, with identical methods for shock and resuscitation being followed, to determine arterial pH, blood gas analysis, lactate, pyruvate, and organs' enzyme activities at various time points. The MAP was monitored for 6 h in both populations. Results Pyruvate Ringer's solution significantly increased the survival rate of rats subjected to fatal shock and receiving pyruvate Ringer's solution (Group P) by 1.5 times the survival rate in Group L at 24 h after fluid resuscitation (55.6% vs. 22.2%, respectively; p  
ISSN:0736-4679
2352-5029
DOI:10.1016/j.jemermed.2013.04.062