Aortic Arterial Stiffness is a Moderate Predictor of Cardiovascular Disease in Patients With Psoriasis Vulgaris

Psoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensiti...

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Bibliographic Details
Published in:Angiology 2014-01, Vol.65 (1), p.74-78
Main Authors: Balta, Ilknur, Balta, Sevket, Demirkol, Sait, Celik, Turgay, Ekiz, Ozlem, Cakar, Mustafa, Sarlak, Hakan, Ozoguz, Pınar, Iyisoy, Atila
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atherosclerosis - physiopathology
C-Reactive Protein - metabolism
Cardiovascular Diseases - blood
Cardiovascular Diseases - physiopathology
Female
Humans
Male
Middle Aged
Psoriasis - blood
Psoriasis - physiopathology
Risk Factors
Vascular Stiffness - physiology
Young Adult
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Summary:Psoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319713485805