Oral rush desensitization for cow milk allergy: Clinical and immunological follow-up

The aim of this study was to evaluate the safety and efficacy of oral rush desensitization in children with cow milk allergy. Prospective study. We included IgE-mediated cow milk allergy children over 3 years in 3 Spanish hospitals. Increasing doses of cow milk for 5 days from 1 cc of 1% to 200 cc o...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2013-12, Vol.79 (6), p.346-351
Main Authors: González Jiménez, D, Larrea Tamayo, E, Díaz Martin, J J, Molinos Norniella, C, Pérez Solis, D, Menéndez Arias, C, Jiménez Treviño, S, Bousoño García, C
Format: Article
Language:Spanish
Subjects:
Adolescent
Child
Child, Preschool
Desensitization, Immunologic - adverse effects
Desensitization, Immunologic - methods
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Milk Hypersensitivity - immunology
Milk Hypersensitivity - therapy
Mouth
Prospective Studies
Treatment Outcome
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Summary:The aim of this study was to evaluate the safety and efficacy of oral rush desensitization in children with cow milk allergy. Prospective study. We included IgE-mediated cow milk allergy children over 3 years in 3 Spanish hospitals. Increasing doses of cow milk for 5 days from 1 cc of 1% to 200 cc of pure milk were administered. Clinical follow-up was conducted and we compared specific IgE levels at onset, 6, 12 and 24 months after desensitization. We included 18 children (13 males) between 3 and 14 years (mean 5.96). A total of 271 doses were administered; there were 55 adverse reactions (84% mild). At the end of the protocol, 100% showed some degree of tolerance (39% total). Full tolerance was achieved in 72% of patients after two years. Two children failed to achieve tolerance. There was a significant decrease in the levels of specific IgE to cow milk and alpha-lactalbumin at 24 months, and to casein at 6, 12 and 24 months, compared to baseline. Oral rush desensitization is a safe and effective therapeutic option for patients with persistent cow milk allergy to medium term.
ISSN:1695-9531
DOI:10.1016/j.anpedi.2013.04.006