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Intratumoral inflammation is associated with more aggressive prostate cancer
Purpose Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease. Methods The slides of prostatectomy specimens were reviewed by a...
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| Published in: | World journal of urology 2013-12, Vol.31 (6), p.1497-1503 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c372t-14766fece72a31ae064bc480052e686733c915aaf97f7b9d88a3de8364b17ae93 |
| container_end_page | 1503 |
| container_issue | 6 |
| container_start_page | 1497 |
| container_title | World journal of urology |
| container_volume | 31 |
| creator | Klink, Joseph C. Bañez, Lionel L. Gerber, Leah Lark, Amy Vollmer, Robin T. Freedland, Stephen J. |
| description | Purpose
Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease.
Methods
The slides of prostatectomy specimens were reviewed by a board-certified pathologist on 287 men from a Veterans Affairs Medical Center treated with radical prostatectomy from 1992 to 2004. The area with the greatest tumor burden was scored in a blinded manner for the degree of inflammation: absent, mild, or marked. We used logistic and Cox proportional hazards regression analysis to examine whether categorically coded inflammation score was associated with adverse pathology and biochemical progression, respectively.
Results
No inflammation was found in 49 men (17 %), while 153 (53 %) and 85 (30 %) had mild and marked inflammation. During a median follow-up of 77 months, biochemical recurrence occurred among 126 (44 %) men. On multivariate analysis, more inflammation was associated with greater risk of positive margins, capsular penetration, and seminal vesicle invasion (all
p
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| doi_str_mv | 10.1007/s00345-013-1065-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1459972180</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1459972180</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-14766fece72a31ae064bc480052e686733c915aaf97f7b9d88a3de8364b17ae93</originalsourceid><addsrcrecordid>eNp1kE1PwzAMhiMEYmPwA7igSly4FJImTdIjmviSJnGBc-Sl7sjUj5G0IP49GR0IIXHywY9f2w8hp4xeMkrVVaCUizyljKeMyjzVe2TKBOepVpncJ1OqMpGKQvMJOQphTSlTkuaHZJLxXEgl1ZQsHtreQz80nYc6cW1VQ9NA77o2cSGBEDrroMcyeXf9SxIpTGC18hiCe8Nk47vQx3ZiobXoj8lBBXXAk12dkefbm6f5fbp4vHuYXy9Sy1XWp0woKSu0qDLgDJBKsbRCU5pnKLVUnNuC5QBVoSq1LEqtgZeoecSYAiz4jFyMuXH_64ChN40LFusaWuyGYJjIi0JlTNOInv9B193g23jdF8V5VMIixUbKxoeCx8psvGvAfxhGzVa1GVWbqNpsVRsdZ852ycOywfJn4tttBLIRCLHVrtD_Wv1v6idTj4jw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1459331761</pqid></control><display><type>article</type><title>Intratumoral inflammation is associated with more aggressive prostate cancer</title><source>Springer Link</source><creator>Klink, Joseph C. ; Bañez, Lionel L. ; Gerber, Leah ; Lark, Amy ; Vollmer, Robin T. ; Freedland, Stephen J.</creator><creatorcontrib>Klink, Joseph C. ; Bañez, Lionel L. ; Gerber, Leah ; Lark, Amy ; Vollmer, Robin T. ; Freedland, Stephen J.</creatorcontrib><description>Purpose
Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease.
Methods
The slides of prostatectomy specimens were reviewed by a board-certified pathologist on 287 men from a Veterans Affairs Medical Center treated with radical prostatectomy from 1992 to 2004. The area with the greatest tumor burden was scored in a blinded manner for the degree of inflammation: absent, mild, or marked. We used logistic and Cox proportional hazards regression analysis to examine whether categorically coded inflammation score was associated with adverse pathology and biochemical progression, respectively.
Results
No inflammation was found in 49 men (17 %), while 153 (53 %) and 85 (30 %) had mild and marked inflammation. During a median follow-up of 77 months, biochemical recurrence occurred among 126 (44 %) men. On multivariate analysis, more inflammation was associated with greater risk of positive margins, capsular penetration, and seminal vesicle invasion (all
p
< 0.05). Marked inflammation was associated with increased PSA recurrence risk when adjusting for preoperative features only (HR 2.08, 95 % CI 1.02–4.24), but not after adjusting for pathologic features.
Conclusions
Inflammation within prostate cancer was associated with more advanced disease, although it is unclear whether aggressive disease caused increased inflammation or inflammation caused aggressive disease.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-013-1065-8</identifier><identifier>PMID: 23546767</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Aged ; Biopsy ; Disease Progression ; Humans ; Inflammation - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Oncology ; Original Article ; Prognosis ; Prostate - pathology ; Prostate - surgery ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Regression Analysis ; Retrospective Studies ; Severity of Illness Index ; Urology</subject><ispartof>World journal of urology, 2013-12, Vol.31 (6), p.1497-1503</ispartof><rights>Springer-Verlag Berlin Heidelberg (outside the USA) 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-14766fece72a31ae064bc480052e686733c915aaf97f7b9d88a3de8364b17ae93</citedby><cites>FETCH-LOGICAL-c372t-14766fece72a31ae064bc480052e686733c915aaf97f7b9d88a3de8364b17ae93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23546767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klink, Joseph C.</creatorcontrib><creatorcontrib>Bañez, Lionel L.</creatorcontrib><creatorcontrib>Gerber, Leah</creatorcontrib><creatorcontrib>Lark, Amy</creatorcontrib><creatorcontrib>Vollmer, Robin T.</creatorcontrib><creatorcontrib>Freedland, Stephen J.</creatorcontrib><title>Intratumoral inflammation is associated with more aggressive prostate cancer</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease.
Methods
The slides of prostatectomy specimens were reviewed by a board-certified pathologist on 287 men from a Veterans Affairs Medical Center treated with radical prostatectomy from 1992 to 2004. The area with the greatest tumor burden was scored in a blinded manner for the degree of inflammation: absent, mild, or marked. We used logistic and Cox proportional hazards regression analysis to examine whether categorically coded inflammation score was associated with adverse pathology and biochemical progression, respectively.
Results
No inflammation was found in 49 men (17 %), while 153 (53 %) and 85 (30 %) had mild and marked inflammation. During a median follow-up of 77 months, biochemical recurrence occurred among 126 (44 %) men. On multivariate analysis, more inflammation was associated with greater risk of positive margins, capsular penetration, and seminal vesicle invasion (all
p
< 0.05). Marked inflammation was associated with increased PSA recurrence risk when adjusting for preoperative features only (HR 2.08, 95 % CI 1.02–4.24), but not after adjusting for pathologic features.
Conclusions
Inflammation within prostate cancer was associated with more advanced disease, although it is unclear whether aggressive disease caused increased inflammation or inflammation caused aggressive disease.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Prostate - pathology</subject><subject>Prostate - surgery</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwzAMhiMEYmPwA7igSly4FJImTdIjmviSJnGBc-Sl7sjUj5G0IP49GR0IIXHywY9f2w8hp4xeMkrVVaCUizyljKeMyjzVe2TKBOepVpncJ1OqMpGKQvMJOQphTSlTkuaHZJLxXEgl1ZQsHtreQz80nYc6cW1VQ9NA77o2cSGBEDrroMcyeXf9SxIpTGC18hiCe8Nk47vQx3ZiobXoj8lBBXXAk12dkefbm6f5fbp4vHuYXy9Sy1XWp0woKSu0qDLgDJBKsbRCU5pnKLVUnNuC5QBVoSq1LEqtgZeoecSYAiz4jFyMuXH_64ChN40LFusaWuyGYJjIi0JlTNOInv9B193g23jdF8V5VMIixUbKxoeCx8psvGvAfxhGzVa1GVWbqNpsVRsdZ852ycOywfJn4tttBLIRCLHVrtD_Wv1v6idTj4jw</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Klink, Joseph C.</creator><creator>Bañez, Lionel L.</creator><creator>Gerber, Leah</creator><creator>Lark, Amy</creator><creator>Vollmer, Robin T.</creator><creator>Freedland, Stephen J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Intratumoral inflammation is associated with more aggressive prostate cancer</title><author>Klink, Joseph C. ; Bañez, Lionel L. ; Gerber, Leah ; Lark, Amy ; Vollmer, Robin T. ; Freedland, Stephen J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-14766fece72a31ae064bc480052e686733c915aaf97f7b9d88a3de8364b17ae93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Prostate - pathology</topic><topic>Prostate - surgery</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klink, Joseph C.</creatorcontrib><creatorcontrib>Bañez, Lionel L.</creatorcontrib><creatorcontrib>Gerber, Leah</creatorcontrib><creatorcontrib>Lark, Amy</creatorcontrib><creatorcontrib>Vollmer, Robin T.</creatorcontrib><creatorcontrib>Freedland, Stephen J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klink, Joseph C.</au><au>Bañez, Lionel L.</au><au>Gerber, Leah</au><au>Lark, Amy</au><au>Vollmer, Robin T.</au><au>Freedland, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intratumoral inflammation is associated with more aggressive prostate cancer</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>31</volume><issue>6</issue><spage>1497</spage><epage>1503</epage><pages>1497-1503</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Purpose
Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease.
Methods
The slides of prostatectomy specimens were reviewed by a board-certified pathologist on 287 men from a Veterans Affairs Medical Center treated with radical prostatectomy from 1992 to 2004. The area with the greatest tumor burden was scored in a blinded manner for the degree of inflammation: absent, mild, or marked. We used logistic and Cox proportional hazards regression analysis to examine whether categorically coded inflammation score was associated with adverse pathology and biochemical progression, respectively.
Results
No inflammation was found in 49 men (17 %), while 153 (53 %) and 85 (30 %) had mild and marked inflammation. During a median follow-up of 77 months, biochemical recurrence occurred among 126 (44 %) men. On multivariate analysis, more inflammation was associated with greater risk of positive margins, capsular penetration, and seminal vesicle invasion (all
p
< 0.05). Marked inflammation was associated with increased PSA recurrence risk when adjusting for preoperative features only (HR 2.08, 95 % CI 1.02–4.24), but not after adjusting for pathologic features.
Conclusions
Inflammation within prostate cancer was associated with more advanced disease, although it is unclear whether aggressive disease caused increased inflammation or inflammation caused aggressive disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23546767</pmid><doi>10.1007/s00345-013-1065-8</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Biopsy Disease Progression Humans Inflammation - pathology Male Medicine Medicine & Public Health Middle Aged Nephrology Oncology Original Article Prognosis Prostate - pathology Prostate - surgery Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Regression Analysis Retrospective Studies Severity of Illness Index Urology |
| title | Intratumoral inflammation is associated with more aggressive prostate cancer |
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