Intratumoral inflammation is associated with more aggressive prostate cancer

Purpose Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease. Methods The slides of prostatectomy specimens were reviewed by a...

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Bibliographic Details
Published in:World journal of urology 2013-12, Vol.31 (6), p.1497-1503
Main Authors: Klink, Joseph C., Bañez, Lionel L., Gerber, Leah, Lark, Amy, Vollmer, Robin T., Freedland, Stephen J.
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Biopsy
Disease Progression
Humans
Inflammation - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Oncology
Original Article
Prognosis
Prostate - pathology
Prostate - surgery
Prostatectomy
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Regression Analysis
Retrospective Studies
Severity of Illness Index
Urology
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Summary:Purpose Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease. Methods The slides of prostatectomy specimens were reviewed by a board-certified pathologist on 287 men from a Veterans Affairs Medical Center treated with radical prostatectomy from 1992 to 2004. The area with the greatest tumor burden was scored in a blinded manner for the degree of inflammation: absent, mild, or marked. We used logistic and Cox proportional hazards regression analysis to examine whether categorically coded inflammation score was associated with adverse pathology and biochemical progression, respectively. Results No inflammation was found in 49 men (17 %), while 153 (53 %) and 85 (30 %) had mild and marked inflammation. During a median follow-up of 77 months, biochemical recurrence occurred among 126 (44 %) men. On multivariate analysis, more inflammation was associated with greater risk of positive margins, capsular penetration, and seminal vesicle invasion (all p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-013-1065-8