Randomized cross-over trial of short-term water-only fasting: Metabolic and cardiovascular consequences

Abstract Background and aims Routine, periodic fasting is associated with a lower prevalence of coronary artery disease (CAD). Animal studies show that fasting may increase longevity and alter biological parameters related to longevity. We evaluated whether fasting initiates acute changes in biomark...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2013-11, Vol.23 (11), p.1050-1057
Main Authors: Horne, B.D, Muhlestein, J.B, Lappé, D.L, May, H.T, Carlquist, J.F, Galenko, O, Brunisholz, K.D, Anderson, J.L
Format: Article
Language:English
Subjects:
Adult
bicarbonates
biomarkers
Biomarkers - blood
Body Mass Index
Caloric restriction
Cardiovascular
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
clinical trials
coronary artery disease
Cross-Over Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - prevention & control
Energy restriction
Erythrocyte
erythrocyte count
Fasting
Fasting - adverse effects
Fasting - physiology
Female
FGF-21
genes
hematocrit
Hemoglobin
high density lipoprotein cholesterol
human growth
Human growth hormone
Humans
Hypertriglyceridemia - blood
Hypertriglyceridemia - epidemiology
Hypertriglyceridemia - prevention & control
ingestion
longevity
Male
metabolic diseases
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Metabolic Syndrome - prevention & control
Middle Aged
risk
Risk Factors
somatotropin
triacylglycerols
Triglycerides - blood
Utah - epidemiology
volunteers
Water - administration & dosage
Weight Loss
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Summary:Abstract Background and aims Routine, periodic fasting is associated with a lower prevalence of coronary artery disease (CAD). Animal studies show that fasting may increase longevity and alter biological parameters related to longevity. We evaluated whether fasting initiates acute changes in biomarker expression in humans that may impact short- and long-term health. Methods and results Apparently-healthy volunteers ( N  = 30) without a recent history of fasting were enrolled in a randomized cross-over trial. A one-day water-only fast was the intervention and changes in biomarkers were the study endpoints. Bonferroni correction required p  ≤ 0.00167 for significance ( p  
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2012.09.007