PHARMACOKINETIC DISPOSITION AND TISSUE DISTRIBUTION OF BISPHENOL A IN RATS AFTER INTRAVENOUS ADMINISTRATION

This study examined the dose-linearity pharmacokinetics of bisphenol A, a U.S. Environmental Protection Agency (EPA) classified endocrine disruptor, in rats following iv administration. Upon iv injection of 0.2, 0.5, 1, or 2 mg/kg, serum levels of bisphenol A declined biexponentially, with mean init...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2000-09, Vol.61 (2), p.131-139
Main Author: Sun Dong Yoo, Beom Soo Shin, Seung Jun Kwack, Byung Mu Lee, Kui Lea Park, Soon-Young Han, Hyung Sik Kim
Format: Article
Language:English
Subjects:
Air Pollutants, Occupational - pharmacokinetics
Animals
Area Under Curve
Benzhydryl Compounds
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chromatography, High Pressure Liquid
Injections, Intravenous
Male
Medical sciences
Organ Size - drug effects
Phenols - administration & dosage
Phenols - pharmacokinetics
Rats
Rats, Sprague-Dawley
Spectrophotometry, Ultraviolet
Tissue Distribution
Toxicology
Various organic compounds
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Summary:This study examined the dose-linearity pharmacokinetics of bisphenol A, a U.S. Environmental Protection Agency (EPA) classified endocrine disruptor, in rats following iv administration. Upon iv injection of 0.2, 0.5, 1, or 2 mg/kg, serum levels of bisphenol A declined biexponentially, with mean initial distribution and elimination half-life ranges of 4?8.2 min and 38.6?62.2 min, respectively. There were no significant alterations in the systemic clearance rate (mean range 90.1?123.6 ml/min/kg) and the steady-state volume of distribution (mean range 4.6?6.0 L/kg) as a function of the administered dose. In addition, the area under the serum concentration?time curve linearly rose as the dose was increased. In a second study, bisphenol A was given by simultaneous iv bolus injection plus infusion to steady state, and levels were measured in serum and various organs. When expressed in concentration terms (e.g., amount accumulated per gram organ weight), bisphenol A was found predominantly in the lung, followed by kidneys, thyroid, stomach, heart, spleen, testes, liver, and brain. Ratios of the organ to serum bisphenol A concentrations exceeded unity for all the organs examined (ratio range 2.0? 5.8) except for brain (ratio 0.75). Given the high systemic clearance and short elimination half-life, bisphenol A is unlikely to accumulate significantly in the rat.
ISSN:1528-7394
0098-4108
1087-2620
2381-3504
DOI:10.1080/00984100050120415