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Cytotoxicity of lindane and paraquat to human hepatoma cell lines
Using the Hep 3B and Hep G2 human cell lines, the cytotoxic effects of lindane and paraquat on viability, growth, lactate dehydrogenase release, ATPase and glutathione contents, enzyme activities, and membrane fluidity were determined. The extensive data are tabulated. Both compounds were cytotoxic....
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| Published in: | Bulletin of environmental contamination and toxicology 1999-01, Vol.62 (1), p.16-24 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c431t-a15179896977a1ad7b72317e34328f9ce1f17f4aa8c495dcaca838d01716ef0a3 |
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| container_end_page | 24 |
| container_issue | 1 |
| container_start_page | 16 |
| container_title | Bulletin of environmental contamination and toxicology |
| container_volume | 62 |
| creator | Descampiaux, B. (Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France.) Cotelle, N Catteau, J.P Peucelle, C Leroux, J.M Erb, F |
| description | Using the Hep 3B and Hep G2 human cell lines, the cytotoxic effects of lindane and paraquat on viability, growth, lactate dehydrogenase release, ATPase and glutathione contents, enzyme activities, and membrane fluidity were determined. The extensive data are tabulated. Both compounds were cytotoxic. For paraquat, the differing results between the two cell lines were attributed to the higher NADPH cytochrome P-450 reductase activity level in Hep G2 cells, which increased the oxido-reductive metabolism of paraquat, leading to a more massive production of superoxide radicals than in the Hep 3B cells. |
| doi_str_mv | 10.1007/s001289900835 |
| format | article |
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(Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France.)</au><au>Cotelle, N</au><au>Catteau, J.P</au><au>Peucelle, C</au><au>Leroux, J.M</au><au>Erb, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity of lindane and paraquat to human hepatoma cell lines</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1999-01</date><risdate>1999</risdate><volume>62</volume><issue>1</issue><spage>16</spage><epage>24</epage><pages>16-24</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><notes>T01</notes><notes>T10</notes><notes>1999004940</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Using the Hep 3B and Hep G2 human cell lines, the cytotoxic effects of lindane and paraquat on viability, growth, lactate dehydrogenase release, ATPase and glutathione contents, enzyme activities, and membrane fluidity were determined. 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| identifier | ISSN: 0007-4861 |
| ispartof | Bulletin of environmental contamination and toxicology, 1999-01, Vol.62 (1), p.16-24 |
| issn | 0007-4861 1432-0800 |
| language | eng |
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| subjects | Adenosine Triphosphate - metabolism Animals Biological and medical sciences Carcinoma, Hepatocellular - physiopathology Cell Division Cytotoxicity Free Radicals - toxicity Glutathione - metabolism Herbicides - toxicity Hexachlorocyclohexane - toxicity Humans Insecticides - toxicity L-Lactate Dehydrogenase - drug effects LINDANE LINDANO Liver Neoplasms, Experimental - physiopathology Medical sciences PARACUAT PARAQUAT Paraquat - toxicity Pesticides, fertilizers and other agrochemicals toxicology TOXICIDAD TOXICITE TOXICITY Toxicology Tumor Cells, Cultured |
| title | Cytotoxicity of lindane and paraquat to human hepatoma cell lines |
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