Cytotoxicity of lindane and paraquat to human hepatoma cell lines

Using the Hep 3B and Hep G2 human cell lines, the cytotoxic effects of lindane and paraquat on viability, growth, lactate dehydrogenase release, ATPase and glutathione contents, enzyme activities, and membrane fluidity were determined. The extensive data are tabulated. Both compounds were cytotoxic....

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1999-01, Vol.62 (1), p.16-24
Main Authors: Descampiaux, B. (Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France.), Cotelle, N, Catteau, J.P, Peucelle, C, Leroux, J.M, Erb, F
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Biological and medical sciences
Carcinoma, Hepatocellular - physiopathology
Cell Division
Cytotoxicity
Free Radicals - toxicity
Glutathione - metabolism
Herbicides - toxicity
Hexachlorocyclohexane - toxicity
Humans
Insecticides - toxicity
L-Lactate Dehydrogenase - drug effects
LINDANE
LINDANO
Liver Neoplasms, Experimental - physiopathology
Medical sciences
PARACUAT
PARAQUAT
Paraquat - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
TOXICIDAD
TOXICITE
TOXICITY
Toxicology
Tumor Cells, Cultured
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Summary:Using the Hep 3B and Hep G2 human cell lines, the cytotoxic effects of lindane and paraquat on viability, growth, lactate dehydrogenase release, ATPase and glutathione contents, enzyme activities, and membrane fluidity were determined. The extensive data are tabulated. Both compounds were cytotoxic. For paraquat, the differing results between the two cell lines were attributed to the higher NADPH cytochrome P-450 reductase activity level in Hep G2 cells, which increased the oxido-reductive metabolism of paraquat, leading to a more massive production of superoxide radicals than in the Hep 3B cells.
ISSN:0007-4861
1432-0800
DOI:10.1007/s001289900835