Fragmented QRS as a predictor of arrhythmic events in patients with hypertrophic obstructive cardiomyopathy

Objectives This study aims to determine whether fragmented QRS (fQRS) in the surface electrocardiogram (ECG) at implantable cardioverter defibrillator (ICD) implant can predict arrhythmic events using appropriate therapy delivered by the ICD as a surrogate. Background Hypertrophic obstructive cardio...

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Bibliographic Details
Published in:Journal of interventional cardiac electrophysiology 2013-12, Vol.38 (3), p.159-165
Main Authors: Femenía, Francisco, Arce, Maurico, Van Grieken, Jorge, Trucco, Emilce, Mont, Luis, Abello, Mauricio, Merino, José L., Rivero-Ayerza, Máximo, Gorenek, Bulent, Rodriguez, Carlos, Hopman, Wilma M., Baranchuk, Adrian
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac - diagnosis
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - prevention & control
Cardiology
Cardiomyopathy, Hypertrophic - diagnosis
Cardiomyopathy, Hypertrophic - epidemiology
Cardiomyopathy, Hypertrophic - prevention & control
Child
Child, Preschool
Comorbidity
Defibrillators, Implantable
Electrocardiography - methods
Electrocardiography - statistics & numerical data
Female
Humans
Internationality
Male
Medicine
Medicine & Public Health
Middle Aged
Prevalence
Prognosis
Reproducibility of Results
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Young Adult
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Summary:Objectives This study aims to determine whether fragmented QRS (fQRS) in the surface electrocardiogram (ECG) at implantable cardioverter defibrillator (ICD) implant can predict arrhythmic events using appropriate therapy delivered by the ICD as a surrogate. Background Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic disorder associated with life-threatening arrhythmias frequently requiring an ICD. Seeking a noninvasive method of risk stratification remains a challenge. Methods This paper is a retrospective, multicenter study of patients with HOCM and ICD. Surface 12-lead ECGs were analyzed. Appropriate therapy was validated by a blinded Core Lab. Univariate and multivariate analyses were performed. A p value of
ISSN:1383-875X
1572-8595
DOI:10.1007/s10840-013-9829-z