Stable right ventricular size and function during short-term follow-up in patients with pulmonary regurgitation after tetralogy of Fallot repair

Aim To assess changes in ventricular size and function over time in conservatively treated adult patients with repaired tetralogy of Fallot (TOF) and significant pulmonary regurgitation (PR). Materials and methods Patients with repaired TOF who had undergone more than one cardiac magnetic resonance...

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Published in:Clinical radiology 2013-12, Vol.68 (12), p.1206-1211
Main Authors: Śpiewak, M, Małek, Ł.A, Petryka, J, Biernacka, E.K, Hoffman, P, Demkow, M, Miśko, J, Rużyłło, W
Format: Article
Language:English
Subjects:
Child, Preschool
Female
Heart Ventricles - anatomy & histology
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Magnetic Resonance Imaging
Male
Pulmonary Valve Insufficiency - physiopathology
Pulmonary Valve Insufficiency - surgery
Radiology
Tetralogy of Fallot - physiopathology
Tetralogy of Fallot - surgery
Time Factors
Ventricular Function, Right - physiology
Young Adult
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Summary:Aim To assess changes in ventricular size and function over time in conservatively treated adult patients with repaired tetralogy of Fallot (TOF) and significant pulmonary regurgitation (PR). Materials and methods Patients with repaired TOF who had undergone more than one cardiac magnetic resonance study were identified. To confine the cause of ventricular size and function deviation to PR, patients with residual ventricular septal defect, more than mild regurgitation at a valve other than the pulmonary valve, and known coronary artery disease were excluded. Results The final analysis included 27 adults with PR fraction >20%. During a follow-up of mean 2.1 ± 0.8 years, there was no change in right ventricular (RV) end-diastolic volume (EDV; 162.1 ± 27.6 versus 164 ± 29.6 ml/m2 , p  = 0.5). Left ventricular (LV) EDV showed a small decrease (85.1 ± 16.2 versus 81.5 ± 14.1 ml/m2 , p  = 0.02). The mean PR fraction, PR volume, and peak RV outflow tract gradient did not change. Additionally, both RV ejection fraction (EF) and LVEF remained stable over the follow-up period (48.1 ± 6.5 versus 48.4 ± 6.7%, p  = 0.83, and 57.3 ± 5.4 versus 57.2 ± 5.1 %, p  = 0.91, respectively). Only two asymptomatic patients (7.4% of the study group) developed symptoms and the remaining did not deteriorate. Conclusion The RVEDV, RVEF, and LVEF remained stable over a mean follow-up of approximately 2 years in the majority of adult patients after TOF repair with significant PR and a wide range of RVEDV.
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2013.06.020