Relationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activity

Background and Aim Neutrophil gelatinase associated lipocalin (NGAL) is a recently identified molecule, which is bacteriostatic, has tissue destructive effects and is pro-inflammatory with chemoattractant molecule binding properties. Our aim was to investigate the relationship between serum NGAL lev...

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Bibliographic Details
Published in:Digestive diseases and sciences 2013-09, Vol.58 (9), p.2587-2593
Main Authors: Yeşil, Atakan, Gönen, Can, Şenateş, Ebubekir, Paker, Nurcan, Gökden, Yasemin, Koçhan, Koray, Erdem, Emrullah Düzgün, Gündüz, Feyza
Format: Article
Language:English
Subjects:
Acute-Phase Proteins
Adolescent
Adult
Aged
Antibacterial agents
Biochemistry
Biomarkers - blood
Case-Control Studies
Colitis, Ulcerative - blood
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - enzymology
Comparative analysis
Crohn Disease - blood
Crohn Disease - diagnosis
Crohn Disease - enzymology
Ethylenediaminetetraacetic acid
Female
Gastroenterology
Hepatology
Humans
Inflammatory bowel disease
Lipocalin-2
Lipocalins - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Prospective Studies
Proto-Oncogene Proteins - blood
Transplant Surgery
Ulcerative colitis
Young Adult
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Summary:Background and Aim Neutrophil gelatinase associated lipocalin (NGAL) is a recently identified molecule, which is bacteriostatic, has tissue destructive effects and is pro-inflammatory with chemoattractant molecule binding properties. Our aim was to investigate the relationship between serum NGAL levels and the type and level of disease activity of IBD. Methods A total of 92 patients [43 with Crohn’s disease (CD) and 49 with ulcerative colitis (UC)], and 30 age- and sex-matched healthy controls (HC) were included in this study. Serum NGAL levels were measured using ELISA. Results Serum NGAL levels were elevated in the IBD group [median 171, range (57–312) ng/mL] compared to the HC group [107 (45–234) ng/mL] ( p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-013-2676-z