Cytokines and neutrophils responses in influenza pneumonia

This case report shows a striking correlation of remarkable brief high levels of pro- and anti-inflammatory cytokines coupled with increased neutrophil activation, followed by a sharp decrease in cytokine levels and increased neutrophil apoptosis associated with the favorable clinical outcomes of a...

Full description

Saved in:
Bibliographic Details
Published in:Infection 2013-10, Vol.41 (5), p.1021-1024
Main Authors: Bordon, J. M., Uriarte, S., Arnold, F. W., Fernandez-Botran, R., Rane, M., Peyrani, P., Cavallazzi, R., Saad, M., Ramirez, J.
Format: Article
Language:English
Subjects:
Case Report
Cytokines - blood
Cytokines - immunology
Family Medicine
Female
General Practice
Humans
Infectious Diseases
Influenza, Human - immunology
Internal Medicine
Medicine
Medicine & Public Health
Middle Aged
Neutrophils - immunology
Pneumonia, Viral - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This case report shows a striking correlation of remarkable brief high levels of pro- and anti-inflammatory cytokines coupled with increased neutrophil activation, followed by a sharp decrease in cytokine levels and increased neutrophil apoptosis associated with the favorable clinical outcomes of a patient with severe influenza infection. The host response examined in our case is not complete, given it did not assess the full spectrum of host response. The brief neutrophil and cytokine response seen in our case in the absence of antiviral therapy and in the presence of methotrexate immunosuppressive therapy rise the question as to whether the latter optimally modulated the macrophage function, resulting in a favorable outcome of severe influenza viral infection.
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-013-0461-8