Chemical and biological study on the essential oil of Artemisia caerulescens L. ssp. densiflora (Viv.)

Artemisia caerulescens L. ssp. densiflora (Viv.) is a wild shrub that grows in the archipelago of La Maddalena, Sardinia, Italy. The antifungal activity of the volatile oil of this sub-species has not been evaluated earlier. This study aimed to identify the main components of the essential oil of A....

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Published in:Natural product research 2013-10, Vol.27 (19), p.1709-1715
Main Authors: Petretto, Giacomo L, Chessa, Mario, Piana, Andrea, Masia, Maria D, Foddai, Marzia, Mangano, Giuseppe, Culeddu, Nicola, Afifi, Fatma U, Pintore, Giorgio
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Artemisia - chemistry
Aspergillus - drug effects
Candida - drug effects
Cyclohexenes - chemistry
Cyclohexenes - pharmacology
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Monoterpenes - chemistry
Monoterpenes - pharmacology
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
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Summary:Artemisia caerulescens L. ssp. densiflora (Viv.) is a wild shrub that grows in the archipelago of La Maddalena, Sardinia, Italy. The antifungal activity of the volatile oil of this sub-species has not been evaluated earlier. This study aimed to identify the main components of the essential oil of A. caerulescens L. ssp. densiflora and to investigate its antifungal activity. Identification of the different components of the essential oil obtained by hydrodistillation from A. caerulescens L. ssp. densiflora was done by both techniques: GC-MS and NMR analyses ((1)H, (13)C, HSQC-NMR). Antifungal activity was evaluated by agar disc diffusion technique against environmental isolates of fungal strains: two yeasts (Rhodotorula spp., Candida spp.), three moulds (Aspergillus spp., Alternaria spp., Fusarium spp.) and a mixture of moulds. GC-MS analysis of the essential oil yielded 42 compounds, out of which, 26 compounds were identified. The main compound was identified as terpinen-4-ol (22%) followed by p-cymene (7.6%) and α-terpineol (3.02%). The significant inhibition spectrum of the essential oil of A. caerulescens L. ssp. densiflora can be considered as an alternative to common disinfectants.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2012.749471