Aluminum-Sensitive Degradation of Amyloid beta -Protein sub(1-40) by Murine and Human Intracellular Enzymes

Amyloid beta -protein (A beta ) accumulates in the characteristic plaques of Alzheimer's disease. A beta is also found in the blood, and may accumulate at the blood brain barrier. Aluminum changes the function and structure of A beta , as well as inhibiting the enzymes involved in degradation o...

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Bibliographic Details
Published in:Neurotoxicology and teratology 1996-11, Vol.18 (6), p.671-671
Main Authors: Banks, William A, Maness, Lawrence M, Banks, Marian F, Kastin, Abba J
Format: Article
Language:English
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Summary:Amyloid beta -protein (A beta ) accumulates in the characteristic plaques of Alzheimer's disease. A beta is also found in the blood, and may accumulate at the blood brain barrier. Aluminum changes the function and structure of A beta , as well as inhibiting the enzymes involved in degradation of the compound. Aluminum does not change blood brain barrier permeability to radioisotope labeled A,bet>. However blood, but not brain clearance of the radiolabeled A beta was increased when aluminum was present. Human and mouse red blood cell lysates showed that intracellular degradation of the radiolabeled A beta was inhibited . Such inhibition depended on aluminum and lysate concentrations, and was inhibited by calcium. However, red blood cells from Alzheimer's patients was no more sensitive to aluminum than red blood cells from controls matched for sex and age.
ISSN:0892-0362