Metabolite Profile Analysis Reveals Functional Effects of 28-Day Vitamin B-6 Restriction on One-Carbon Metabolism and Tryptophan Catabolic Pathways in Healthy Men and Women

Suboptimal vitamin B-6 status, as reflected by low plasma pyridoxal 5′-phosphate (PLP) concentration, is associated with increased risk of vascular disease. PLP plays many roles, including in one-carbon metabolism for the acquisition and transfer of carbon units and in the transsulfuration pathway....

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Published in:The Journal of nutrition 2013-11, Vol.143 (11), p.1719-1727
Main Authors: da Silva, Vanessa R., Rios-Avila, Luisa, Lamers, Yvonne, Ralat, Maria A., Midttun, Øivind, Quinlivan, Eoin P., Garrett, Timothy J., Coats, Bonnie, Shankar, Meena N., Percival, Susan S., Chi, Yueh-Yun, Muller, Keith E., Ueland, Per Magne, Stacpoole, Peter W., Gregory, Jesse F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Creatine - blood
Cystathionine - blood
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammation - blood
Kynurenic Acid - blood
Kynurenine - analogs & derivatives
Kynurenine - blood
Male
Multivariate Analysis
Postprandial Period
Pyridoxal Phosphate - blood
Serine - blood
Tryptophan - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B 6 - administration & dosage
Vitamin B 6 - blood
Vitamin B 6 Deficiency - blood
Young Adult
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Summary:Suboptimal vitamin B-6 status, as reflected by low plasma pyridoxal 5′-phosphate (PLP) concentration, is associated with increased risk of vascular disease. PLP plays many roles, including in one-carbon metabolism for the acquisition and transfer of carbon units and in the transsulfuration pathway. PLP also serves as a coenzyme in the catabolism of tryptophan. We hypothesize that the pattern of these metabolites can provide information reflecting the functional impact of marginal vitamin B-6 deficiency. We report here the concentration of major constituents of one-carbon metabolic processes and the tryptophan catabolic pathway in plasma from 23 healthy men and women before and after a 28-d controlled dietary vitamin B-6 restriction (
ISSN:0022-3166
1541-6100
DOI:10.3945/jn.113.180588