Association of the candidate gene SLC1A1 and obsessive―compulsive disorder in Han Chinese Population

This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese. The G-A-C-G and G-G-T-C haplotypes were found to be significantly...

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Bibliographic Details
Published in:Psychiatry research 2013-10, Vol.209 (3), p.737-739
Main Authors: HAISU WU, XUEMEI WANG, SHUNYING YU, DONGXIANG WANG, JIANHUA CHEN, KAIDA JIANG, LIPING ZHU, ZEPING XIAO, FRALICK, Drew
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Asian Continental Ancestry Group - ethnology
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Case-Control Studies
Excitatory Amino Acid Transporter 3 - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Male
Medical sciences
Obsessive-Compulsive Disorder - epidemiology
Obsessive-Compulsive Disorder - ethnology
Obsessive-Compulsive Disorder - genetics
Obsessive-compulsive disorders
Polymorphism, Single Nucleotide - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese. The G-A-C-G and G-G-T-C haplotypes were found to be significantly associated with OCD in overall samples, male samples and female samples.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2012.12.016