A β‑Boronopeptide Bundle of Known Structure As a Vehicle for Polyol Recognition

Despite significant progress in the design of receptors and sensors for simple polyols and monosaccharides, few synthetic receptors discriminate among multiple saccharide units simultaneously, especially under physiological conditions. Described here is the three-dimensional structure of a supramole...

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Bibliographic Details
Published in:Organic letters 2013-10, Vol.15 (19), p.5048-5051
Main Authors: Melicher, Michael S, Chu, John, Walker, Allison S, Miller, Scott J, Baxter, Richard H. G, Schepartz, Alanna
Format: Article
Language:English
Subjects:
Molecular Structure
Monosaccharides - chemistry
Peptides - chemistry
Polymers - chemistry
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Summary:Despite significant progress in the design of receptors and sensors for simple polyols and monosaccharides, few synthetic receptors discriminate among multiple saccharide units simultaneously, especially under physiological conditions. Described here is the three-dimensional structure of a supramolecular complexa β-peptide bundledesigned for the potential to interact simultaneously with as many as eight discrete monosaccharide units. The preliminary evaluation of this construct as a vehicle for polyol binding is also presented.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol402381n