Resveratrol Decreases Periodontal Breakdown and Modulates Local Levels of Cytokines During Periodontitis in Rats

Background: Resveratrol (3,4′,5‐trihydroxystilbene) is a naturally occurring product found in numerous plants. Among its biologic properties, resveratrol may promote immunomodulatory effects on the host response. This study investigates the effect of continuous administration of resveratrol on the p...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2013-10, Vol.84 (10), p.e58-e64
Main Authors: Casati, Marcio Z., Algayer, Carolina, Cardoso da Cruz, Geisa, Ribeiro, Fernanda V., Casarin, Renato C.V., Pimentel, Suzana P., Cirano, Fabiano R.
Format: Article
Language:English
Subjects:
Alveolar bone loss
Alveolar Bone Loss - immunology
Alveolar Bone Loss - prevention & control
Animals
anti‐bacterial agents
anti‐inflammatory agents
Biofilms - drug effects
Cytokines - drug effects
Dentistry
Disease Models, Animal
Disease Progression
Gingiva - immunology
Immunologic Factors - therapeutic use
Interleukin-17 - analysis
Interleukin-1beta - analysis
Interleukin-4 - analysis
Male
medicinal
periodontitis
Periodontitis - immunology
Periodontitis - prevention & control
Placebos
plants
Random Allocation
Rats
Rats, Wistar
Resveratrol
Stilbenes - therapeutic use
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Summary:Background: Resveratrol (3,4′,5‐trihydroxystilbene) is a naturally occurring product found in numerous plants. Among its biologic properties, resveratrol may promote immunomodulatory effects on the host response. This study investigates the effect of continuous administration of resveratrol on the progression of experimental periodontitis in rats. Methods: Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: 1) daily administration of the placebo solution (control group) or 2) 10 mg/kg resveratrol (RESV group). The therapies were administered systemically for 30 days: for 19 days before periodontitis induction and then for another 11 days. Then, the specimens were processed for morphometric analysis of bone loss, and the gingival tissue surrounding the first molar was collected for quantification of interleukin (IL)‐1β, IL‐4, and IL‐17 using a multiplexing assay. Results: Intergroup comparisons of the morphometric outcomes revealed higher bone loss values in ligated molars and unligated teeth in the control group than the RESV group (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2013.120746