Association between family history of prostate cancer and positive biopsies in a Brazilian screening program

Purpose To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. Methods Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile scr...

Full description

Saved in:
Bibliographic Details
Published in:World journal of urology 2013-10, Vol.31 (5), p.1273-1278
Main Authors: Muller, Roberto L., Faria, Eliney F., Carvalhal, Gustavo F., Reis, Rodolfo B., Mauad, Edmundo C., Carvalho, Andre L., Freedland, Stephen J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biopsy
Brazil
Digital Rectal Examination
Early Detection of Cancer - methods
Family Health
Humans
Logistic Models
Male
Medical History Taking
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Oncology
Original Article
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Retrospective Studies
Risk Factors
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. Methods Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Positive FH was defined as any relative having PCa among screened men. Men were biopsied if they had digital rectal examination suggestive of PCa or PSA >4.0 ng/mL or PSA of 2.5–4 ng/mL with percent free PSA ≤15 %. We analyzed the association between FH and PCa using multivariable logistic regression in the first screening round of the program. Results Positive FH was present in 735 men (4.2 % of total), and they were younger, better educated and more likely to have had previous PCa screening (41.5 vs. 28.5 %; P  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-012-0904-3