Histopathologic assessment of the entire endometrium in asymptomatic women

Summary Knowledge on the nature of the endometrium in women without symptoms of endometrial disease is poor. Therefore, the aim of this prospective study was to describe the endometrium of a cohort of asymptomatic women. The entire endometrium of premenopausal and postmenopausal women was embedded f...

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Bibliographic Details
Published in:Human pathology 2013-10, Vol.44 (10), p.2293-2301
Main Authors: Mingels, Marjanka J.J.M., MD, Geels, Yvette P., MD, Pijnenborg, Johanna M.A., MD, PhD, van der Wurff, Anneke A., MD, PhD, van Tilborg, Angela A.G., PhD, van Ham, Maaike A.P.C., MD, PhD, Massuger, Leon F.A.G., MD, PhD, Bulten, Johan, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atypical hyperplasia
Body mass index
Comorbidity
Diabetes Mellitus - epidemiology
Endometrial Hyperplasia - epidemiology
Endometrial Hyperplasia - pathology
Endometrial neoplasia
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - pathology
Endometrium
Endometrium - pathology
Family medical history
Female
Histopathology
Hormone replacement therapy
Humans
Hypertension - epidemiology
Hysterectomy
Menopause
Middle Aged
Netherlands - epidemiology
Pathology
Postmenopause
Premenopause
Prospective Studies
Uterine prolapse
Uterine Prolapse - epidemiology
Uterine Prolapse - surgery
Womens health
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Summary:Summary Knowledge on the nature of the endometrium in women without symptoms of endometrial disease is poor. Therefore, the aim of this prospective study was to describe the endometrium of a cohort of asymptomatic women. The entire endometrium of premenopausal and postmenopausal women was embedded for histologic examination. All included patients underwent a hysterectomy on indication of uterovaginal prolapse, from July 2011 to October 2012, in 3 hospitals in the South of the Netherlands. Exclusion criteria were symptoms of postmenopausal vaginal blood loss or premenopausal disordered vaginal bleeding. As a result, 68 women were included in the study, 48 women were postmenopausal and 20 were premenopausal. In the endometrium of 10 women, simple hyperplasia was found (15%); 1, complex hyperplasia (2%); 2, simple atypical hyperplasia (3%); 2, complex atypical hyperplasia (3%); and 2, a small focus of intramucosal endometrioid endometrial carcinoma (3%). In general, the endometrium was heterogeneous, and most lesions were not present in the entire endometrium. In conclusion, after examining the entire endometrium, a remarkable high prevalence of endometrial pathology was found in asymptomatic women. The clinical meaning of these lesions is not yet clear, but endometrial pathology may frequently exist without symptoms.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2013.05.011