Effectiveness of paliperidone extended-release for patients with schizophrenia: focus on subjective improvement

Objective This study assessed whether the subjective experience of patients with schizophrenia improved after switching from an oral antipsychotic to flexibly‐dosed paliperidone extended‐release. Methods We conducted a 24‐week, multicenter, non‐comparative, open‐label trial. A total of 387 patients...

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Published in:Human psychopharmacology 2013-03, Vol.28 (2), p.107-116
Main Authors: Na, Kyoung-Sae, Kim, Chul-Eung, Kim, Yong-Sik, Lee, Jong-Il, Han, Wou Sang, Kang, Ung Gu, Park, Doo-Heum, Kim, Bongseog, Jung, Han-Yong, Yoon, Jin-Sang, Lim, Se-Won
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - administration & dosage
Delayed-Action Preparations - administration & dosage
effectiveness
Female
Humans
Isoxazoles - administration & dosage
Male
Middle Aged
paliperidone
Paliperidone Palmitate
Prospective Studies
Pyrimidines - administration & dosage
schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Schizophrenic Psychology
SCL-90-R
switching
Treatment Outcome
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Summary:Objective This study assessed whether the subjective experience of patients with schizophrenia improved after switching from an oral antipsychotic to flexibly‐dosed paliperidone extended‐release. Methods We conducted a 24‐week, multicenter, non‐comparative, open‐label trial. A total of 387 patients with schizophrenia participated the study. The primary study outcome was the change in subjective symptoms measured by the Symptom Checklist‐90‐Revised version (SCL‐90‐R) from baseline. Visual analogue scales were used for sleep and daytime somnolence as secondary subjective assessments. The clinical global impression‐schizophrenia‐severity scale was used to assess overall symptom severity. Social functioning was evaluated by the personal and social performance scale. Adverse events were also evaluated. Results All subjective symptoms measured by the SCL‐90‐R improved significantly. The early responders, who achieved >20% reduction in the SCL‐90‐R within 1 week, maintained significantly lower severity through the 24 weeks. The clinical global impression‐schizophrenia‐severity scale and personal and social performance scores also improved significantly. The visual analogue scales revealed that daytime somnolence improved significantly, whereas nocturnal sleep quality was unaltered. Conclusion Our results suggest that switching to paliperidone extended‐release was associated with improvements in various subjective symptoms, decreased overall symptom severity, and increased social functioning. The results also suggest that early detection and reduction of subjective symptoms are important for treatment outcome. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:0885-6222
1099-1077
DOI:10.1002/hup.2284