Abietane Diterpenes from Hyptis suaveolens

Investigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α‐epoxysuaveolic acid (2), and 14‐O‐methylsuaveolic acid (3), together with eleven known compounds. The structures of 1–3 were established by sp...

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Bibliographic Details
Published in:Chemistry & biodiversity 2013-08, Vol.10 (8), p.1494-1500
Main Authors: Prawatsri, Saowanee, Suksamrarn, Apichart, Chindaduang, Anon, Rukachaisirikul, Thitima
Format: Article
Language:English
Subjects:
Abietanes
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antimycobacterial activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Cytotoxic activity
Diterpenes
Diterpenes, Abietane - chemistry
Diterpenes, Abietane - pharmacology
Humans
Hyptis - chemistry
Hyptis suaveolens
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Neoplasms - drug therapy
Plant Preparations - chemistry
Plant Preparations - pharmacology
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Summary:Investigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α‐epoxysuaveolic acid (2), and 14‐O‐methylsuaveolic acid (3), together with eleven known compounds. The structures of 1–3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201200213