Comparative pulmonary fibrogenic potential of selected particles

The comparative intrapulmonary fibrogenic potential of a number of chemically and physically characterized ashes and dusts was studied. Sprague-Dawley rats were exposed through intratracheal instillation to 5, 15, or 45 mg of stack-collected coal fly ash, electrostatic precipitator hopper-collected...

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Bibliographic Details
Published in:Environmental research 1985-12, Vol.38 (2), p.256-274
Main Authors: Schreider, Jay P., Culbertson, M.Roger, Raabe, Otto G.
Format: Article
Language:English
Subjects:
Air Pollutants - toxicity
Aluminum Silicates - toxicity
Animals
Biological and medical sciences
Carbon - toxicity
Chemical and industrial products toxicology. Toxic occupational diseases
Clay
Coal - adverse effects
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Lung - pathology
Medical sciences
Particle Size
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - pathology
Quartz - toxicity
Rats
Toxicology
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Summary:The comparative intrapulmonary fibrogenic potential of a number of chemically and physically characterized ashes and dusts was studied. Sprague-Dawley rats were exposed through intratracheal instillation to 5, 15, or 45 mg of stack-collected coal fly ash, electrostatic precipitator hopper-collected coal fly ash, bag-house filter-collected coal-oil mixture fly ash, Dowson and Dobson quartz, heated montmorillonite clay, and Mt. St. Helens volcano ash. Following a 3-month postexposure period, the animals were killed and subjected to histological examination. Some fibrosis was produced by all the ashes. However, the effects differed both qualitatively and quantitatively among the various exposure groups. The most severe fibrosis was found in the quartz-treated animals, followed in order of intensity by the heated clay, volcano, ash, hopper coal ash, stack coal ash, and coal-oil mixture ash. No effects were found in the saline-exposed control rats.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(85)90090-8