Effect of Antibodies to Glutamate on Caspase-3 Activity in Brain Structures of Rats with Experimental Alzheimer’s Disease

Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment Aβ 25-35 into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administratio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-02, Vol.154 (4), p.425-427
Main Authors: Kolobov, V. V., Zakharova, I. A., Fomina, V. G., Gorbatov, V. Yu, Davydova, T. V.
Format: Article
Language:eng ; rus
Subjects:
Administration, Intranasal
Alzheimer Disease - drug therapy
Alzheimer Disease - enzymology
Alzheimer's disease
Amyloid beta-protein
Animals
Antibodies
Antibodies - administration & dosage
Antibodies - immunology
Antibodies - therapeutic use
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brain
Caspase 3 - metabolism
Cell Biology
Enzymes
Glutamate
Glutamic Acid - immunology
Internal Medicine
Laboratory Medicine
Male
Pathology
Rats
Rats, Wistar
Viral antibodies
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Summary:Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment Aβ 25-35 into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage reduced enzyme activity in these structures in a rat model of Alzheimer’s disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-1967-x