Commensal bacteria‐dependent select expression of CXCL2 contributes to periodontal tissue homeostasis

Summary The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy intestinal tissue structure and function, their contribution to oral health is poorly understood. A crucial component of periodontal health is the recruitment of neutro...

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Bibliographic Details
Published in:Cellular microbiology 2013-08, Vol.15 (8), p.1419-1426
Main Authors: Zenobia, Camille, Luo, Xiao Long, Hashim, Ahmed, Abe, Toshiharu, Jin, Lijian, Chang, Yucheng, Jin, Zhi Chao, Sun, Jian Xun, Hajishengallis, George, Curtis, Mike A., Darveau, Richard P.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteria - pathogenicity
Bacterial Physiological Phenomena
Chemokine CXCL2 - metabolism
Cytokines - metabolism
Gingiva - metabolism
Gingiva - pathology
Homeostasis - physiology
Immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Myeloid Differentiation Factor 88 - deficiency
Myeloid Differentiation Factor 88 - genetics
Myeloid Differentiation Factor 88 - metabolism
Neutrophils - pathology
Oral hygiene
Periodontium - metabolism
Periodontium - pathology
Receptors, Interleukin-8B - deficiency
Receptors, Interleukin-8B - genetics
Receptors, Interleukin-8B - metabolism
Recruitment
Signal Transduction - physiology
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Summary:Summary The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy intestinal tissue structure and function, their contribution to oral health is poorly understood. A crucial component of periodontal health is the recruitment of neutrophils to periodontal tissue. To elucidate this process, gingival tissues of specific‐pathogen‐free and germ‐free wild‐type mice and CXCR2KO and MyD88KO mice were examined for quantitative analysis of neutrophils and CXCR2 chemoattractants (CXCL1, CXCL2). We show that the recruitment ofneutrophils to the gingival tissue does not require commensal bacterial colonization but is entirely dependent on CXCR2 expression. Strikingly, however, commensal bacteria selectively upregulate the expression of CXCL2, but not CXCL1, in a MyD88‐dependent way that correlates with increased neutrophil recruitment as compared with germ‐free conditions. This is the first evidence that the selective use of chemokine receptor ligands contributes to neutrophil homing to healthy periodontal tissue.
ISSN:1462-5814
1462-5822
DOI:10.1111/cmi.12127