Expression of PARK7 is increased in celiac disease

Recently, it has been suggested that the gene called Parkinson’s disease 7 (PARK7) might be an upstream activator of hypoxia-inducible factor (HIF)-1α, which plays a major role in sustaining intestinal barrier integrity. Furthermore, PARK7 has been proposed to participate in the Toll-like receptor (...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2013-09, Vol.463 (3), p.401-408
Main Authors: Vörös, Péter, Sziksz, Erna, Himer, Leonóra, Ónody, Anna, Pap, Domonkos, Frivolt, Klára, Szebeni, Beáta, Lippai, Rita, Győrffy, Hajnalka, Fekete, Andrea, Brandt, Ferenc, Molnár, Kriszta, Veres, Gábor, Arató, András, Tulassay, Tivadar, Vannay, Ádám
Format: Article
Language:English
Subjects:
Adolescent
Biomarkers - metabolism
Biopsy
Case-Control Studies
Celiac disease
Celiac Disease - diet therapy
Celiac Disease - metabolism
Celiac Disease - pathology
Child
Child, Preschool
Diet, Gluten-Free
Duodenum - metabolism
Duodenum - pathology
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Infant
Intracellular Signaling Peptides and Proteins - metabolism
Male
Medicine
Medicine & Public Health
Oncogene Proteins - metabolism
Original Article
Pathology
Protein Deglycase DJ-1
RNA, Messenger - metabolism
Toll-Like Receptor 4 - metabolism
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Summary:Recently, it has been suggested that the gene called Parkinson’s disease 7 (PARK7) might be an upstream activator of hypoxia-inducible factor (HIF)-1α, which plays a major role in sustaining intestinal barrier integrity. Furthermore, PARK7 has been proposed to participate in the Toll-like receptor (TLR)-dependent regulation of the innate immune system. Our aim was to investigate the involvement of PARK7 in the pathogenesis of coeliac disease (CD). Duodenal biopsy specimens were collected from 19 children with untreated CD, five children with treated CD (maintained on gluten-free diet), and ten children with histologically normal duodenal biopsies. PARK7 mRNA expression and protein level were determined by real-time polymerase chain reaction (PCR) and Western blot, respectively. Localization of PARK7 was visualized by immunofluorescence staining. Protein level of PARK7 increased in the duodenal mucosa of children with untreated CD compared to children with treated CD or to control biopsies ( p
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-013-1443-z