A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation

Objective To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM). Design Cross-sectional study. Setting Hospital. Patient(s) A total of 561 pregnant women: 318 without and 243 with GDM (Nationa...

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Bibliographic Details
Published in:Fertility and sterility 2013-09, Vol.100 (3), p.788-792
Main Authors: Bassols, Judit, Ph.D, Megia, Ana, M.D, Soriano-Rodríguez, Pilar, M.D, Díaz, Marta, Ph.D, Prats-Puig, Anna, Ph.D, Gifre, Magdalena, R.N, Simón-Muela, Inmaculada, M.D, Torrent, Sara, M.D, Borrell, Anna C., M.D, Riera-Socasau, Joan-Carles, M.D., Ph.D, Vendrell, Joan, M.D., Ph.D, de Zegher, Francis, M.D., Ph.D, Ibáñez, Lourdes, M.D., Ph.D, López-Bermejo, Abel, M.D
Format: Article
Language:English
Subjects:
Adult
alleles
Body Mass Index
c-peptide
Cross-Sectional Studies
Diabetes, Gestational - epidemiology
Diabetes, Gestational - genetics
fasting
Female
Gene Frequency
Genetic Association Studies
Genetic Markers
Genetic Predisposition to Disease
genotype
gestational diabetes
glucose
Humans
insulin
insulin resistance
Insulin Resistance - genetics
Internal Medicine
Metabolic Diseases - epidemiology
Metabolic Diseases - genetics
Obstetrics and Gynecology
patients
phenotype
polymorphism
Polymorphism, Single Nucleotide - physiology
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - genetics
pregnant women
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - physiology
risk
Risk Factors
STK11
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Summary:Objective To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM). Design Cross-sectional study. Setting Hospital. Patient(s) A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria). Intervention(s) None. Main Outcome Measures(s) rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and β-cell function [HOMA-IR and -β]) and C-peptide assessed at 24–28 weeks’ gestation. Result(s) In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-β (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m2 ; GG: 24.5 ± 0.6 kg/m2 ) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%). Conclusion(s) In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2013.04.037