Adipokines and endothelial dysfunction in obesity WHO°III

Obesity is closely associated with the metabolic syndrome (MetS) and subsequent low-grade inflammation links to endothelial dysfunction (ED) and cardiovascular disease. The impact of adipokines on retinal ED is not fully understood, in particular not in severe obesity. The aim of the study was to id...

Full description

Saved in:
Bibliographic Details
Published in:Microvascular research 2013-09, Vol.89, p.129-133
Main Authors: Bachmayer, Christine, Kemmer, Anne, Ehrmann, Nadine, Hasenberg, Till, Lammert, Alexander, Hammes, Hans-Peter
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipokines - metabolism
Adiponectin - blood
Adult
Arterioles - pathology
Body Weight
Endothelium, Vascular - pathology
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation
Humans
Inflammation
Male
Metabolic Syndrome - metabolism
Middle Aged
Obesity
Regression Analysis
Retina - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity is closely associated with the metabolic syndrome (MetS) and subsequent low-grade inflammation links to endothelial dysfunction (ED) and cardiovascular disease. The impact of adipokines on retinal ED is not fully understood, in particular not in severe obesity. The aim of the study was to identify the association of the MetS and prespecified adipokines on retinal ED in obesity WHO°III. 92 obese patients (obesity WHO°III) were assessed for the MetS (IDF), neck circumference, adipokines and inflammatory markers (hsCRP, TNFα, Il-6, MCP-1, sICAM, sVCAM, IGF-BP3, RBP 4 and adiponectin). Retinal ED as determined by the arterio-venous-ratio (AVR) and retinal vessel diameters (CRAE, CRVE) was measured using retinal photographs. Obese subjects with MetS (MetS+ group) differed from the MetS− by neck circumference, fasting plasma glucose, insulin, HOMA-IR, triglycerides and HDL-C. Importantly, IL-6, sICAM and adiponectin were significantly different between groups, while measures of retinal ED showed no differences. Univariate linear regression revealed a significant association between neck circumference and ED for patients with MetS, and a significant association between adiponectin and CRAE for patients without MetS. This study shows that ED in obesity WHO°III is independent of MetS or inflammation and that neck circumference has an impact on ED in obesity WHO°III. [Display omitted] •Obesity WHO°III is independently associated with retinal endothelial dysfunction.•The metabolic syndrome is not discriminative for vascular health in obesity WHO°III.•Neck circumference is discriminative for endothelial dysfunction in obesity WHO°III.•Adipokines did not show an impact on endothelial dysfunction in obesity WHO°III.
ISSN:0026-2862
1095-9319
DOI:10.1016/j.mvr.2013.04.007