The effects of age and gender on the relationship between HMGCR promoter-911 SNP (rs33761740) and serum lipids in patients with coronary heart disease

Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR) catalyzes the rate-limiting step of cholesterol biosynthesis. This enzyme is the target of the widely available cholesterol lowering statins. In this population-based case–control study, the frequencies of -911 C>A polymorphism (rs3761740) of the...

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Bibliographic Details
Published in:Gene 2013-10, Vol.528 (2), p.93-98
Main Authors: Akadam-Teker, Basak, Kurnaz, Ozlem, Coskunpinar, Ender, Daglar-Aday, Aynur, Kucukhuseyin, Ozlem, Cakmak, Huseyin Altug, Teker, Erhan, Bugra, Zehra, Ozturk, Oguz, Yilmaz-Aydogan, Hulya
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Age Factors
anthropometric measurements
biosynthesis
blood lipids
blood serum
Case-Control Studies
Cholesterol - blood
Cholesterol, LDL - blood
coronary disease
Coronary Disease - blood
Coronary Disease - epidemiology
Coronary Disease - genetics
Coronary heart disease
fasting
Female
gender
Gene Frequency
genes
Genetic Association Studies
Genetic Predisposition to Disease
genotype
HMGCR
Humans
Hydroxymethylglutaryl CoA Reductases - genetics
hypercholesterolemia
Lipoproteins
low density lipoprotein cholesterol
Male
Middle Aged
Multivariate Analysis
patients
polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide
Prevalence
Promoter Regions, Genetic
regression analysis
restriction fragment length polymorphism
risk
risk factors
Sex Distribution
Sex Factors
single nucleotide polymorphism
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Summary:Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR) catalyzes the rate-limiting step of cholesterol biosynthesis. This enzyme is the target of the widely available cholesterol lowering statins. In this population-based case–control study, the frequencies of -911 C>A polymorphism (rs3761740) of the HMGCR gene in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlations between the different genotypes and hypercholesterolemia with cardiovascular risk factors were analyzed. The HMGCR genotypes were determined in 365 patients with CHD and 365 controls by PCR–RFLP assay. Anthropometric measurements were measured in all participants. There was no significant difference in the genotype frequencies of the HMGCR polymorphism between the male subjects of both patient and control groups, however, the HMGCR-CC genotype was found to be more frequent in female patients with CHD than female controls (p=0.002). The HMGCR-CC genotype showed higher total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels than the CA+AA genotypes in male CHD patients (p=0.018). Due to this significant sex interaction, a multivariate analysis was conducted on the patient group. In the multivariate logistic regression analysis, the HMGCR-CC genotype was significantly associated with age0.05). This analysis confirmed that the HMGCR-CC genotype was associated with elevated TC levels in male CHD patients with age
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2013.07.056