Attractiveness of reformulated OxyContin® tablets: assessing comparative preferences and tampering potential

Reformulated OxyContin® (oxycodone HCl controlled-release or ORF) was developed as a tamper and abuse-deterrent product, to reduce the risk of product abuse, misuse and their consequences. This noninterventional single-session study asked participants who were medically-healthy recreational opioid u...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2013-09, Vol.27 (9), p.808-816
Main Authors: Sellers, Edward M, Perrino, Peter J, Colucci, Salvatore V, Harris, Stephen C
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - chemistry
Biological and medical sciences
Brand preferences
Chemistry, Pharmaceutical - methods
Comparative studies
Delayed-Action Preparations
Drug abuse
Drug addiction
Female
Humans
Male
Medical sciences
Neuropharmacology
Opioid-Related Disorders - prevention & control
Oxycodone - administration & dosage
Oxycodone - chemistry
Pharmacology. Drug treatments
Prescription Drug Misuse - prevention & control
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychotropic drugs
Tablets - administration & dosage
Tablets - chemistry
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Summary:Reformulated OxyContin® (oxycodone HCl controlled-release or ORF) was developed as a tamper and abuse-deterrent product, to reduce the risk of product abuse, misuse and their consequences. This noninterventional single-session study asked participants who were medically-healthy recreational opioid users, aged 18 years and older, to consider how they would use commonly available supplies to tamper with placebo ORF and placebo original OxyContin (OC) tablets, and how they would assess the attractiveness of tampering and abusing ORF tablets, as compared with other opioid formulations. Participants provided information on past opioid use, and they assessed the properties of five nonhypothetical oxycodone products and two hypothetical oxycodone products. Participants provided feedback on tampering preferences, preferred tamper methods for each product, overall tampering potential and product preferences. We had 30 participants (27 males and 3 females; mean age 35 years, range 18–51) complete both the interview and tampering sessions. Participants judged OC as the most attractive, valuable, desirable and most likely to be tampered with, from among all opioid products studied. By contrast, they rated ORF as the least attractive, least valuable, least desirable, and least likely to be tampered with among all the nonhypothetical opioid products studied. These results suggested that recreational drug abusers view ORF tablets as tamper-deterrent products.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881113493364