Associations of IGF-1 gene variants and milk protein intake with IGF-I concentrations in infants at age 6 months — Results from a randomized clinical trial

Abstract Objective The interplay of genetic and nutritional regulation of the insulin-like growth factor-I axis in children is unclear. Therefore, potential gene–nutrient effects on serum levels of the IGF-I axis in a formula feeding trial were studied. Design European multicenter randomized clinica...

Full description

Saved in:
Bibliographic Details
Published in:Growth hormone & IGF research 2013-10, Vol.23 (5), p.149-158
Main Authors: Rzehak, Peter, Grote, Veit, Lattka, Eva, Weber, Martina, Gruszfeld, Dariusz, Socha, Piotr, Closa-Monasterolo, Ricardo, Escribano, Joaquín, Giovannini, Marcello, Verduci, Elvira, Goyens, Philippe, Martin, Françoise, Langhendries, Jean-Paul, Demmelmair, Hans, Klopp, Norman, Illig, Thomas, Koletzko, Berthold
Format: Article
Language:English
Subjects:
Advanced Basic Science
Age Factors
Breast Feeding
Eating - physiology
Endocrinology & Metabolism
Female
Follow-Up Studies
Genetic Association Studies
Humans
Infant
Infant Formula
Infant Nutritional Physiological Phenomena
Infant, Newborn - growth & development
Insulin-Like Growth Factor I - analysis
Insulin-Like Growth Factor I - genetics
Male
Milk Proteins - metabolism
Polymorphism, Single Nucleotide
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective The interplay of genetic and nutritional regulation of the insulin-like growth factor-I axis in children is unclear. Therefore, potential gene–nutrient effects on serum levels of the IGF-I axis in a formula feeding trial were studied. Design European multicenter randomized clinical trial of 1090 term, formula-fed infants assigned to receive cow's milk-based infant and follow-on formulae with lower (LP: 1.25 and 1.6 g/100 mL) or higher (HP: 2.05 and 3.2 g/100 mL) protein contents for the first 12 months of life; a comparison group of 588 breastfed infants (BF) was included. Eight single nucleotide polymorphisms (SNPs) of the IGF-1- (rs6214, rs1520220, rs978458, rs7136446, rs10735380, rs2195239, rs35767, and rs35766) and two of the IGFBP-3- (rs1496495, rs6670) gene were analyzed. Serum levels of total and free IGF-I, IGFBP-3 and the molar ratio IGF-1/IGFBP-3 at age 6 months were regressed on determined SNPs and feeding groups in 501 infants. Results IGF-1 -SNPs rs1520220, rs978458, and rs2195239 significantly increased total-IGF-I and molar-ratio IGF-I/IGFBP-3 by ~ 1.3 ng/mL and ~ 1.3 per allele, respectively; compared to LP infants concentration and molar-ratio were increased in HP by ~ 1.3 ng/mL and ~ 1.3 and decreased in BF infants by ~ 0.6 ng/mL and ~ 0.6, respectively. IGFBP-3 was only affected by the BF group with ~ 450 ng/mL lower levels than the LP group. No gene-feeding-group interaction was detected for any SNP, even without correction for multiple testing. Conclusions Variants of the IGF-1- gene play an important role in regulating serum levels of the IGF-I axis but there is no gene-protein-interaction. The predominant nutritional regulation of IGF-I and IGFBP-3 gives further evidence that higher protein intake contributes to metabolic programming of growth.
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2013.05.002