Structural correlates of pain in joints with osteoarthritis

Structural correlates of pain in joints with osteoarthritis

Summary Objective To describe the insights on the epidemiology of pain-structure association and the ramifications of these studies for clinical trials. Design Narrative review summarizing the pertinent literature in this area, summarizing some of the methodologic challenges inherent and proposing s...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2013-09, Vol.21 (9), p.1170-1178
Main Authors: Hunter, D.J, Guermazi, A, Roemer, F, Zhang, Y, Neogi, T
Format: Article
Language:eng
Subjects:
Arthralgia - diagnosis
Arthralgia - epidemiology
Arthralgia - physiopathology
Chronic Pain - diagnosis
Chronic Pain - epidemiology
Chronic Pain - physiopathology
Humans
Imaging
MRI
Osteoarthritis
Osteoarthritis, Knee - diagnosis
Osteoarthritis, Knee - epidemiology
Osteoarthritis, Knee - physiopathology
Pain
Prevalence
Radiography
Rheumatology
Risk Factors
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Summary:Summary Objective To describe the insights on the epidemiology of pain-structure association and the ramifications of these studies for clinical trials. Design Narrative review summarizing the pertinent literature in this area, summarizing some of the methodologic challenges inherent and proposing some research initiatives to further understanding of this complex science. Results The predominant symptom in most patients presenting with osteoarthritis (OA) is pain. Over recent years a number of imaging based studies have narrowed the discord between structural findings on imaging and symptoms. The interpretation of pain in OA is still enigmatic and difficult to deal with both for clinicians and scientists. Conclusions We would envisage that over the next few years many of the pressing questions pertaining to research into the structure pain relationship will continue to be addressed. With this, we can expect clinically appropriate therapeutic advance.
ISSN:1063-4584
1522-9653