Clinical picture of infiltrating lobular carcinoma of the breast: an analysis of 96 patients

The aim of this study was to present the clinical picture of infiltrating lobular carcinoma (ILC) of the breast. A detailed analysis was performed for the group of 96 ILC patients subject to initial surgical treatment in the Krakow Branch of Centre of Oncology between 1983 and 1996. The investigated...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2013, Vol.34 (3), p.222-226
Main Authors: Skotnicki, P, Blecharz, P, Jakubowicz, J, Reinfuss, M, Strzepek, Ł
Format: Article
Language:English
Subjects:
Age Factors
Aged
Axilla
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Carcinoma, Lobular - epidemiology
Carcinoma, Lobular - pathology
Female
Humans
Incidence
Lymph Nodes - pathology
Middle Aged
Neoplasm Metastasis
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Summary:The aim of this study was to present the clinical picture of infiltrating lobular carcinoma (ILC) of the breast. A detailed analysis was performed for the group of 96 ILC patients subject to initial surgical treatment in the Krakow Branch of Centre of Oncology between 1983 and 1996. The investigated group was selected out of 2,347 breast cancer patients treated during that period, based on re-examination of histologic specimens of the initial patient group. The following distinctive demographic and clinical features of ILC were found: average age of patients: 59 years (37 - 83); average duration of pathological symptoms: five months; most frequent site of primary tumor: upper outer quadrant (54.2%); primary tumor Stage: I/II0 (64.6%), III0A (35.4%); tumor size in breast: up to five cm (69.8%), larger than five cm (30.2%); no axillary lymph nodes involvement in 51% of patients; multifocality of lesions in 10% of patients; contralateral disease occurrence in eight percent of patients; atypical pattern of distant metastases, e.g. gastrointestinal system, gynaecologic organs, and cerebral meninges. Based on this analysis as well as on literature reports, it was found that the fundamental differences between ILC and infiltrating ductal carcinoma (IDC) included demographic and clinical features as patient age, primary tumor size at diagnosis, incidence of multifocality and contralateral disease, sites of distant metastases, and histopathological status of axillary lymph nodes.
ISSN:0392-2936