Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We stu...

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Bibliographic Details
Published in:International Journal of Obesity 2012-11, Vol.36 (11), p.1442-1449
Main Authors: MORENO-NAVARRETE, J. M, ORTEGA, F, FERNANDEZ-REAL, J. M, SERINO, M, LUCHE, E, WAGET, A, PARDO, G, SALVADOR, J, RICART, W, FRÜHBECK, G, BURCELIN, R
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Adipose Tissue
Analysis
Animals
Binding proteins
Biological and medical sciences
Biomarkers - blood
Body Mass Index
Carrier Proteins - blood
Complications and side effects
Cross-Sectional Studies
Diabetes
Diet
Endocrinology
Enzyme-Linked Immunosorbent Assay
Female
Glucagon
Glucose
Humans
Immune system
Inflammation - blood
Insulin Resistance
Lipids
Male
Medical sciences
Membrane Glycoproteins - blood
Metabolic diseases
Metabolism
Mice
Nutrition research
Obesity
Obesity - blood
Peptides
Physiological aspects
Plasma
Proteins
Risk factors
Spain
Systemic diseases
Weight control
Weight Loss
White people
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Summary:Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μg ml(-1), P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2011.256