Genes of detoxification are important modulators of hereditary medullary thyroid carcinoma risk

Summary Context Different inherited profiles of genes involved in cellular mechanisms of activation and detoxification of carcinogenic products can provide specific protection or determine the risk for cancer. Low‐penetrance polymorphic genes related to the biotransformation of environmental toxins...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2013-08, Vol.79 (2), p.288-293
Main Authors: Barbieri, R. B., Bufalo, N. E., Cunha, L. L., Assumpção, L. V. M., Maciel, R. M. B., Cerutti, J. M., Ward, L. S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arylamine N-Acetyltransferase - genetics
Biological and medical sciences
Cancer
Carcinoma, Neuroendocrine
Cytochrome P-450 CYP1A1 - genetics
Cytochrome P-450 CYP1A2 - genetics
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Glutathione S-Transferase pi - genetics
Humans
Inactivation, Metabolic - genetics
Logistic Models
Male
Malignant tumors
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Phenotype
Polymorphism, Genetic
Proto-Oncogene Proteins c-ret - genetics
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
Tumor Suppressor Protein p53 - genetics
Vertebrates: endocrinology
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Summary:Summary Context Different inherited profiles of genes involved in cellular mechanisms of activation and detoxification of carcinogenic products can provide specific protection or determine the risk for cancer. Low‐penetrance polymorphic genes related to the biotransformation of environmental toxins have been associated with susceptibility to and the phenotype of, human tumours. Objective To investigate the role of germline inheritance of polymorphisms in CYP1A2*F, CYP1A1 m1, GSTP1, NAT2 and TP53 genes in hereditary medullary thyroid carcinoma (HMTC) patients. Design This study was developed in University of Campinas (Unicamp). Patients We studied 132 patients with HMTC, 88 first‐degree relatives of HMTC patients and 575 control individuals. Measurements All patients with MTC and their relatives were sequenced for the RET gene and five genes were genotyped using TaqMan® system. Results We observed that the inheritance of CYP1A2*F (OR = 2·10; 95% CI = 1·11–3·97; P = 0·022), GSTP1 (OR = 4·41; 95% CI = 2·47–7·88; P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12136