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Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue
Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium. In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and bro...
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Published in: | Pharmacological reports 2013-05, Vol.65 (3), p.751-755 |
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creator | Bishnoi, Mahendra Kiran Kondepudi, Kanthi Gupta, Aakriti Karmase, Aniket Boparai, Ravneet K. |
description | Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium.
In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and brown (BAT) adipose tissues was investigated using real time PCR (RT-PCR).
TRPV1, TRPV3, TRPM8, TRPC4, TRPC6 were differentially expressed in preadipocytes and adipocytes suggesting their significance in adipogenesis. Genes for multiple TRP channels were also expressed in murineWAT and BAT, out of which TRPV4, TRPV6 and TRPC6 showed differential expression.
Present study demonstrates the expression of TRP channels in mouse cell lines and adipose tissues. |
doi_str_mv | 10.1016/S1734-1140(13)71055-7 |
format | article |
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In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and brown (BAT) adipose tissues was investigated using real time PCR (RT-PCR).
TRPV1, TRPV3, TRPM8, TRPC4, TRPC6 were differentially expressed in preadipocytes and adipocytes suggesting their significance in adipogenesis. Genes for multiple TRP channels were also expressed in murineWAT and BAT, out of which TRPV4, TRPV6 and TRPC6 showed differential expression.
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In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and brown (BAT) adipose tissues was investigated using real time PCR (RT-PCR).
TRPV1, TRPV3, TRPM8, TRPC4, TRPC6 were differentially expressed in preadipocytes and adipocytes suggesting their significance in adipogenesis. Genes for multiple TRP channels were also expressed in murineWAT and BAT, out of which TRPV4, TRPV6 and TRPC6 showed differential expression.
Present study demonstrates the expression of TRP channels in mouse cell lines and adipose tissues.</description><subject>3T3-L1 Cells</subject><subject>3T3L1 cells</subject><subject>adipocyte</subject><subject>Adipocytes - metabolism</subject><subject>adipogenesis</subject><subject>Adipogenesis - genetics</subject><subject>adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>arrays</subject><subject>calcium</subject><subject>Cell Line</subject><subject>Drug Safety and Pharmacovigilance</subject><subject>Mice</subject><subject>Pharmacotherapy</subject><subject>Pharmacy</subject><subject>Short Communication</subject><subject>Transient Receptor Potential Channels - genetics</subject><subject>Transient Receptor Potential Channels - metabolism</subject><subject>TRP channel</subject><issn>1734-1140</issn><issn>2299-5684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkV1rFDEUhoModq3-hEou24vRk6_JzFWRpX7AgqLrdcgmZ9qU2WSazEj992a7tbeFwCGc931P8hxCzhh8YMDaj7-YFrJhTMI5ExeagVKNfkFWnPd9o9pOviSrJ8kJeVPKLYBkXKjX5ISLXkELsCLT1f2UsZSQIk0D3S_jHKYR6TbbWALGmf5Eh9OcMv2R5noPdqTuxsaII73GiIWGWG05RKRiK5oNow7HkY7h0LPRU-vDlArSOZSy4FvyarBjwXeP9ZT8_ny1XX9tNt-_fFt_2jROaT03A_RSyk53iB32XIOS1mtwrZecg_Jct8J1w7ADobjl9didhtarXqlOeidOyfkxd8rpbsEym30oh5fZiGkphkneAgfQUKXqKHU5lZJxMFMOe5v_GgbmANs8wDYHkoYJ8wDb6Op7_zhi2e3RP7n-062C9igotRWvMZvbtORYv_1s8uXRiJXQn1CNxdVlOPQho5uNT-GZhH--MJ6p</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Bishnoi, Mahendra</creator><creator>Kiran Kondepudi, Kanthi</creator><creator>Gupta, Aakriti</creator><creator>Karmase, Aniket</creator><creator>Boparai, Ravneet K.</creator><general>Elsevier B.V</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue</title><author>Bishnoi, Mahendra ; Kiran Kondepudi, Kanthi ; Gupta, Aakriti ; Karmase, Aniket ; Boparai, Ravneet K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-f09444878ee8e927054ad70c6d42205d2763c8ffb0352a22a2ab706d595584dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>3T3-L1 Cells</topic><topic>3T3L1 cells</topic><topic>adipocyte</topic><topic>Adipocytes - metabolism</topic><topic>adipogenesis</topic><topic>Adipogenesis - genetics</topic><topic>adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>arrays</topic><topic>calcium</topic><topic>Cell Line</topic><topic>Drug Safety and Pharmacovigilance</topic><topic>Mice</topic><topic>Pharmacotherapy</topic><topic>Pharmacy</topic><topic>Short Communication</topic><topic>Transient Receptor Potential Channels - genetics</topic><topic>Transient Receptor Potential Channels - metabolism</topic><topic>TRP channel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bishnoi, Mahendra</creatorcontrib><creatorcontrib>Kiran Kondepudi, Kanthi</creatorcontrib><creatorcontrib>Gupta, Aakriti</creatorcontrib><creatorcontrib>Karmase, Aniket</creatorcontrib><creatorcontrib>Boparai, Ravneet K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bishnoi, Mahendra</au><au>Kiran Kondepudi, Kanthi</au><au>Gupta, Aakriti</au><au>Karmase, Aniket</au><au>Boparai, Ravneet K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue</atitle><jtitle>Pharmacological reports</jtitle><stitle>Pharmacol. Rep</stitle><addtitle>Pharmacol Rep</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>65</volume><issue>3</issue><spage>751</spage><epage>755</epage><pages>751-755</pages><issn>1734-1140</issn><eissn>2299-5684</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium.
In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and brown (BAT) adipose tissues was investigated using real time PCR (RT-PCR).
TRPV1, TRPV3, TRPM8, TRPC4, TRPC6 were differentially expressed in preadipocytes and adipocytes suggesting their significance in adipogenesis. Genes for multiple TRP channels were also expressed in murineWAT and BAT, out of which TRPV4, TRPV6 and TRPC6 showed differential expression.
Present study demonstrates the expression of TRP channels in mouse cell lines and adipose tissues.</abstract><cop>Cham</cop><pub>Elsevier B.V</pub><pmid>23950600</pmid><doi>10.1016/S1734-1140(13)71055-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 3T3-L1 Cells 3T3L1 cells adipocyte Adipocytes - metabolism adipogenesis Adipogenesis - genetics adipose tissue Adipose Tissue - metabolism Animals arrays calcium Cell Line Drug Safety and Pharmacovigilance Mice Pharmacotherapy Pharmacy Short Communication Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism TRP channel |
title | Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue |
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