Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue

Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium. In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and bro...

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Bibliographic Details
Published in:Pharmacological reports 2013-05, Vol.65 (3), p.751-755
Main Authors: Bishnoi, Mahendra, Kiran Kondepudi, Kanthi, Gupta, Aakriti, Karmase, Aniket, Boparai, Ravneet K.
Format: Article
Language:English
Subjects:
3T3-L1 Cells
3T3L1 cells
adipocyte
Adipocytes - metabolism
adipogenesis
Adipogenesis - genetics
adipose tissue
Adipose Tissue - metabolism
Animals
arrays
calcium
Cell Line
Drug Safety and Pharmacovigilance
Mice
Pharmacotherapy
Pharmacy
Short Communication
Transient Receptor Potential Channels - genetics
Transient Receptor Potential Channels - metabolism
TRP channel
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Summary:Calcium and its signaling have a role in adipogenesis. Transient Receptor Potential (TRP) channels are non-selective cation channels with a high permeability to calcium. In the present study the expression of multiple TRP channels on mouse 3T3-L1 preadipocyte and adipocyte cells, white (WAT) and brown (BAT) adipose tissues was investigated using real time PCR (RT-PCR). TRPV1, TRPV3, TRPM8, TRPC4, TRPC6 were differentially expressed in preadipocytes and adipocytes suggesting their significance in adipogenesis. Genes for multiple TRP channels were also expressed in murineWAT and BAT, out of which TRPV4, TRPV6 and TRPC6 showed differential expression. Present study demonstrates the expression of TRP channels in mouse cell lines and adipose tissues.
ISSN:1734-1140
2299-5684
DOI:10.1016/S1734-1140(13)71055-7