Indocyanine green‐augmented diode laser therapy vs. long‐pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial

Summary Background Telangiectatic leg veins (TLV) represent a common cosmetic problem. Near infrared lasers have been widely used in treatment because of their deeper penetration into the dermis, but with varying degrees of success, particularly because of different vessel diameters. Indocyanine gre...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2013-08, Vol.169 (2), p.365-373
Main Authors: Klein, A., Buschmann, M., Babilas, P., Landthaler, M., Bäumler, W.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Coloring Agents - administration & dosage
Cosmetic Techniques
Dermatology
Female
Humans
Indocyanine Green - administration & dosage
Infusions, Intravenous
Laser Therapy - adverse effects
Laser Therapy - methods
Lasers, Semiconductor - therapeutic use
Leg - blood supply
Medical sciences
Middle Aged
Prospective Studies
Telangiectasis - surgery
Treatment Outcome
Vascular disorders of the skin
Young Adult
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Summary:Summary Background Telangiectatic leg veins (TLV) represent a common cosmetic problem. Near infrared lasers have been widely used in treatment because of their deeper penetration into the dermis, but with varying degrees of success, particularly because of different vessel diameters. Indocyanine green (ICG)‐augmented diode laser treatment (ICG+DL) may present an alternative treatment option. Objectives This trial evaluates the efficacy of ICG+DL in the treatment of TLV and compares the safety and efficacy of therapy with the standard treatment, the long‐pulsed neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser. Methods In a prospective randomized controlled clinical trial, 29 study participants with TLV were treated with a Nd:YAG laser (λem = 1064 nm, 160–240 J cm−2, 65‐ms pulse duration, 5‐mm spot size) and ICG+DL (λem = 810 nm, 60–110 J cm−2, 48–87‐ms pulse duration, 6‐mm spot size; total ICG dose 4 mg kg−1) in a side‐by‐side comparison in one single treatment setting that included histological examination in four participants. Two blinded investigators and the participants assessed clearance rate, cosmetic appearance and adverse events up to 3 months after treatment. Results According to both the investigators' and participants' assessment, clearance rates were significantly better after ICG+DL therapy than after Nd:YAG laser treatment (P 
ISSN:0007-0963
1365-2133
DOI:10.1111/bjd.12415