Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis

The present study was designed to investigate the effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Complete transection of spinal cord (thoraci...

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Bibliographic Details
Published in:Journal of rehabilitation research and development 2013, Vol.50 (1), p.17-30
Main Authors: Manjhi, Jayanand, Kumar, Suneel, Behari, Jitendra, Mathur, Rashmi
Format: Article
Language:English
Subjects:
Animal experimentation
Animals
Bone density
Care and treatment
Complications and side effects
Health aspects
Magnetic Fields
Male
Osteoporosis
Osteoporosis - etiology
Osteoporosis - prevention & control
Proteins
Rats
Rats, Wistar
Risk factors
Rodents
Spinal cord injuries
Spinal Cord Injuries - complications
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Summary:The present study was designed to investigate the effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Complete transection of spinal cord (thoracic 11 vertebra) was surgically performed under anesthesia, whereas in the sham group only laminectomy was done. Post-SCI day 1, rats were either exposed (2 h/d × 8 wk) to ELF-MF (17.96 micro-Tesla, 50 Hz; SCI+MF group) or sham exposed (SCI group). Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. All the rats were sacrificed 8 wk post-SCI; tibia and femur bones were isolated for the analysis of bone mineral content (BMC; total calcium [Ca], phosphorus [P], carbon [C]), bone mineral density (BMD), and biochemical status (osteocalcin, collagen I, alkaline phosphatase). The BBB score decreased post-SCI, which partially recovered after ELF-MF. In SCI rats, there was a statistically significant decrease in BMC, Ca, P, C, BMD, and biochemical level in both the bones as compared with the sham group, which was attenuated in SCI+MF rats except the C content. Electron microscopic study revealed the enhancement of microstructural composition and compactness in cortical and trabecular parts of treated bones. The results suggest that the chronic (2 h/d × 8 wk) ELF-MF exposure (17.96 micro-Tesla, 50 Hz) to SCI rats is effective in attenuating SCI-induced osteoporosis.
ISSN:0748-7711
1938-1352
DOI:10.1682/JRRD.2011.12.0248