The diagnostic value of high-frequency ultrasonography in biliary atresia

BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields much improved spatial resolution and therefore, might show better image in BA diagnost...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2013-08, Vol.12 (4), p.415-422
Main Authors: Jiang, Li-Ping, Chen, Yun-Chao, Ding, Lu, Liu, Xiao-Ling, Li, Kai-Yan, Huang, Dao-Zhong, Zhou, Ai-Yun, Zhang, Qing-Ping
Format: Article
Language:English
Subjects:
atresia
biliary
biliary atresia
Biliary Atresia - complications
Biliary Atresia - diagnostic imaging
Cholangiopancreatography, Magnetic Resonance
Endocrinology & Metabolism
Female
Gallbladder - diagnostic imaging
Gastroenterology and Hepatology
Hepatic Artery - diagnostic imaging
high-frequency
high-frequency ultrasonography
Humans
Infant
jaundice
Jaundice - etiology
Male
neonatal
neonatal jaundice
Portal Vein - diagnostic imaging
Sensitivity and Specificity
ultrasonography
Ultrasonography - methods
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Summary:BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields much improved spatial resolution and therefore, might show better image in BA diagnostic examination. The present study was to evaluate the HUS on the diagnosis of BA in infants with jaundice. METHODS: Fifty-one infants with neonatal jaundice were scanned with ultrasonography. Images included gallbladder, bile duct, right hepatic artery (RHA), portal vein (PV) and triangular cord (TC) sign, magnetic resonance imaging and additionally laboratory tests and histopathology reports were assessed. RESULTS: Twenty-three BA and 28 non-BA cases were con firmed. The sensitivity, specificity, and accuracy of HUS were 91.3%, 92.9%, and 92.2%, respectively. All of these indices were significantly higher than those of conventional ultrasonography (P<0.01) and MR cholangiopancreatography (P<0.05). The HUS features, included a positive TC sign, an increased RHA diameter and RHA-diameter to portal-vein-diameter ratio (RHA/PV) and abnormal gallbladder, were important in the diagnosis of BA. CONCLUSION: HUS provided better imaging of BA and should be considered as a primary modality in the differential diagnosis of infantile jaundice.
ISSN:1499-3872
DOI:10.1016/S1499-3872(13)60065-X