Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: The Bambuì cohort study of aging (1997–2008)

Abstract Objectives To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design A population-based prospective cohort study of all residents in Bambuì, south-eastern Braz...

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Bibliographic Details
Published in:Maturitas 2013-09, Vol.76 (1), p.57-63
Main Authors: Correa Leite, Maria Léa, Moriguchi, Emilio H, Lima-Costa, Maria Fernanda
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aging - genetics
Alcohol consumption
Alcohol Drinking - genetics
Alcohol Drinking - physiopathology
Apolipoprotein E
Apolipoproteins E - genetics
Biological and medical sciences
Blood pressure
Blood Pressure - genetics
Body Mass Index
Brazil
Female
Genotype
Gynecology. Andrology. Obstetrics
Humans
Hypertension - genetics
Hypertension - physiopathology
Internal Medicine
Medical sciences
Menopause
Metabolic diseases
Middle Aged
Obesity
Obesity - genetics
Obesity - physiopathology
Obstetrics and Gynecology
Polymorphism, Genetic
Postmenopause
Prospective Studies
Puberal and climacteric disorders (male and female)
Reference Values
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Summary:Abstract Objectives To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis. Results Alcohol consumption was associated with high levels of systolic and diastolic BP in an age × genotype-dependent manner only in the non-obese women (BMI < 27 kg/m2 ). Among those with the ɛ3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg ( p = 0.022) and 10.7 mmHg ( p = 0.002), and disappeared in the older age groups, in which drinking was associated with systolic/diastolic hypertension if the non-obese women were ɛ4 carriers. Conclusion In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the ɛ3/3 ApoE genotype, and late in ɛ4 carriers. We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2013.05.012