Impact of chorionicity on first-trimester nuchal translucency screening in ART twin pregnancies

ABSTRACT Objective Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies. Metho...

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Bibliographic Details
Published in:Prenatal diagnosis 2013-08, Vol.33 (8), p.722-725
Main Authors: Flöck, A., Reinsberg, J., Berg, C., Gembruch, U., Geipel, A.
Format: Article
Language:English
Subjects:
Adult
Chorion - diagnostic imaging
Female
Fetofetal Transfusion - diagnostic imaging
Fetofetal Transfusion - epidemiology
Humans
Nuchal Translucency Measurement - statistics & numerical data
Pregnancy
Pregnancy Trimester, First
Pregnancy, Twin - statistics & numerical data
Reproductive Techniques, Assisted - statistics & numerical data
Retrospective Studies
Twins, Dizygotic - statistics & numerical data
Twins, Monozygotic - statistics & numerical data
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Summary:ABSTRACT Objective Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies. Methods Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 weeks conceived either spontaneously (n = 362) or with ART (n = 344). The group with spontaneous conception included 234 DC (64.6%) and 128 MC (35.4%) pregnancies. In the ART group, 326 were DC (94.7%) and 18 were MC (5.3%). NT values were transformed into multiples of median (MoM). Results In the DC group, no significant differences between ART and spontaneously conceived twins (NT MoM 1.06 ± 0.28 vs 1.03 ± 0.29; p > 0.05) were observed. NT MoM of MC ART twins was higher compared with spontaneous MC twins (1.23 ± 0.82 vs 0.99 ± 0.27; p = 0.011). Although the incidence of twin‐to‐twin transfusion syndrome (TTTS) was higher among ART twins (11.1% vs 4.7%), inter‐twin NT difference was similar between pregnancies with TTTS (0.42 ± 0.21) or without (0.40 ± 0.71). Conclusions Measurement of NT thickness in DC ART twins achieves comparable results with twins conceived spontaneously. Conclusions in MC twins are limited; however, higher NT MoM was not related to TTTS or selective intrauterine growth restriction. © 2013 John Wiley & Sons, Ltd. What's already known about this topic? Measurement of nuchal translucency (NT) is an effective and validated method to detect chromosomal abnormalities in singletons and twins. Most studies reported comparable screening results in assisted reproduction treatment (ART) singletons compared with spontaneous conceptions. However, ART twins are less extensively investigated, especially with respect to chorionicity. What does this study add? This study is the first analysis about the impact of chorionicity on NT screening in ART and spontaneous twins in a large cohort.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.4107